LEADER 03689nam 2200589Ia 450 001 9910782388003321 005 20230607222142.0 010 $a1-281-95657-0 010 $a9786611956578 010 $a981-281-101-X 035 $a(CKB)1000000000537983 035 $a(StDuBDS)AH24685593 035 $a(SSID)ssj0000221431 035 $a(PQKBManifestationID)11192553 035 $a(PQKBTitleCode)TC0000221431 035 $a(PQKBWorkID)10161297 035 $a(PQKB)10996464 035 $a(MiAaPQ)EBC1681753 035 $a(WSP)00004774 035 $a(Au-PeEL)EBL1681753 035 $a(CaPaEBR)ebr10255448 035 $a(CaONFJC)MIL195657 035 $a(OCoLC)815755997 035 $a(EXLCZ)991000000000537983 100 $a20020214d2001 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe physical foundation of protein architecture$b[electronic resource] /$fNobuhiko Saito, Yukio Kobayashi 210 $aSingapore ;$aRiver Edge, N.J. $cWorld Scientific$dc2001 215 $a1 online resource (156p. ) $cillustrations 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a981-02-4710-9 320 $aIncludes bibliographical references (p. 135-142) and index. 327 $aGeneralities: helix-coil transition in polypeptide; some aspects of protein folding. Mechanism of protein folding: island model; a-helical proteins; lysozyme and phospholipase; bovine pancreatic trypsin inhibitor; flavodoxin and thioredoxin; ferredoxin. Folding of a protein of unknown structure: ab initio method of prediction of protein structure; search for the conformation of minimum energy. Topics related to protein structures: phase transition; module; molecular chaperones; membrane proteins; structure prediction based on protein data. 330 8 $aThis work elucidates the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding.$bA protein requires its own three-dimensional structure for its biological activity. If a chemical agent is added, the biological activity is lost, and the three-dimensional structure is destroyed to become a random coil state. But when the chemical agent is removed, the biological activity is recovered, implying that the random coil state turns back into the original complex structure spontaneously. This is an astonishing event.;"The Physical Foundation of Protein Architecture" is intended to solve this mystery from the physicochemical basis by elucidating the mechanism of various processes in protein folding. The main features of protein folding are shown to be described by the island model with long range hydrophobic interaction which is capable of finding the specific residue, and the lampshade criterion for disulfide bonding. Various proteins with known structure are refolded, with the purpose of uncovering the mechanism of protein folding. In addition, ab initio method for predicting protein structure from its amino acid sequence is proposed. 606 $aProteins$xStructure 606 $aBiomolecules$xStructure 615 0$aProteins$xStructure. 615 0$aBiomolecules$xStructure. 676 $a572.6 700 $aSaito?$b Nobuhiko$048405 701 $aKobayashi$b Yukio$0150970 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782388003321 996 $aPhysical foundation of protein architecture$9471799 997 $aUNINA