LEADER 05525nam 2200685Ia 450 001 9910458113103321 005 20200520144314.0 010 $a1-281-86755-1 010 $a9786611867553 010 $a1-86094-949-5 035 $a(CKB)1000000000401837 035 $a(EBL)1193441 035 $a(SSID)ssj0000292189 035 $a(PQKBManifestationID)12064756 035 $a(PQKBTitleCode)TC0000292189 035 $a(PQKBWorkID)10269149 035 $a(PQKB)11318809 035 $a(MiAaPQ)EBC1193441 035 $a(WSP)0000P500 035 $a(Au-PeEL)EBL1193441 035 $a(CaPaEBR)ebr10698849 035 $a(CaONFJC)MIL186755 035 $a(OCoLC)827945006 035 $a(EXLCZ)991000000000401837 100 $a20071011d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aComparative physiology, natural animal models, and clinical medicine$b[electronic resource] $einsights into clinical medicine from animal adaptations /$fMichael A. Singer 210 $aLondon $cImperial College Press$dc2007 215 $a1 online resource (292 p.) 300 $aDescription based upon print version of record. 311 $a1-86094-782-4 320 $aIncludes bibliographical references and index. 327 $aAcknowledgements; Introduction; Chapter 1 Diabetes Mellitus; Introduction; Blood Glucose Values in Birds; Do Birds Suffer Adverse Consequences from a High Blood Glucose Concentration; Anatomic and Physiologic Design Features; Eye; Retinal nutrient supply; Retinal vascularization in mammals; Avian and mammalian retinal physiology and development; Diabetic retinopathy; Kidney; Kidney anatomy and function in birds and mammals; Diabetic nephropathy; (a) Renal glucose transporters; (b) Juxtaglomerular apparatus; Glycated hemoglobin; Concluding Remarks and Future Research; References 327 $aChapter 2 Chronic Renal FailureIntroduction; Metabolic Rate and Renal Function; Nitrogen and Urea Metabolism and Protein Turnover; Nitrogen and urea metabolism; Urea transport proteins; Protein turnover; Alterations in urea and protein metabolism in chronic renal failure; Additional Aspects of Renal Failure; Natural Animal Model; Bear and Small Mammal Hibernators; Concluding Remarks and Future Directions; References; Chapter 3 Atherosclerotic Vascular Disease; Introduction; Atherosclerosis in Mammals; Biology of the Arterial System: Implications for the Genesis of Atherosclerosis in Mammals 327 $aGenesis of Atherosclerotic LesionsNatural Animal Model: The Fish; Fish Coronary Circulation; Fish Coronary Artery Thickenings; Genesis of Fish Lesions; Biomechanical Factors in Fish; Dietary In.uences and Role of Cholesterol in Fish; Biology of the Vascular Smooth Muscle in Fish; Concluding Remarks: What Can We Learn From the Fish as a Natural Model?; References; Chapter 4 Disuse Osteoporosis and Disuse Muscle Atrophy; Disuse Osteoporosis; Bone biology; Parathyroid hormone (PTH); Vitamin D; Leptin; Mechanical stress; Disuse osteoporosis 327 $aNatural animal model: American black bear (Ursus americanus)Bone homeostasis in the bear: research questions; Disuse Muscle Atrophy; Maintenance of muscle mass; Protein degradation: mechanisms; Animal models; Studies in humans and small mammal hibernators; Humans; Small mammal hibernators; Natural animal model: the American black bear; The bear: a perspective; References; Chapter 5 Ammonia Toxicity; Ammonia Tolerance and Metabolism; Ammonia tolerance; Ammonia metabolism; Brain Ammonia Metabolism; Glutamatergic Neurons; General considerations (Purves et al., 2004) 327 $aGlutamate, a Neurotransmitter and the "Glutamate-Glutamine" CycleMechanism of Ammonia Neurotoxicity; Neuropathological effects; Effects on Brain Energy Metabolism; Effects on Glutamatergic Synapses; Ammonia and the Fish Central Nervous System; Role of glutamine; Glutamate; Brain energy metabolism; NMDA receptors; Summary; References; Chapter 6 Hypoxia/Ischemia; Cerebral Blood Flow: Its Regulation; Brain Energy Metabolism; Oxygen and Oxygen/Glucose Deprivation and the Brain; General features of neuronal response; Anoxia tolerant mammalian neurons; Neonatal brain; Dorsal vagal neurons 327 $aNeonatal neurons 330 $aThis book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we ca 606 $aDiseases$xAnimal models 606 $aPhysiology, Comparative 606 $aLaboratory animals 608 $aElectronic books. 615 0$aDiseases$xAnimal models. 615 0$aPhysiology, Comparative. 615 0$aLaboratory animals. 676 $a616.0076 676 $a616.0273 700 $aSinger$b Michael A$g(Michael Allan),$f1940-$0996605 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458113103321 996 $aComparative physiology, natural animal models, and clinical medicine$92284996 997 $aUNINA LEADER 03349nam 2200661Ia 450 001 9910782382603321 005 20230617005912.0 010 $a1-281-80313-8 010 $a9786611803131 010 $a0-567-23612-9 035 $a(CKB)1000000000542386 035 $a(EBL)435945 035 $a(OCoLC)320324874 035 $a(SSID)ssj0000275183 035 $a(PQKBManifestationID)11210171 035 $a(PQKBTitleCode)TC0000275183 035 $a(PQKBWorkID)10330856 035 $a(PQKB)11096416 035 $a(MiAaPQ)EBC435945 035 $a(Au-PeEL)EBL435945 035 $a(CaPaEBR)ebr10250896 035 $a(CaONFJC)MIL180313 035 $a(OCoLC)893333751 035 $a(EXLCZ)991000000000542386 100 $a20050523d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aWriting and ancient Near Eastern society$b[electronic resource] $epapers in honour of Alan R. Millard /$fedited by Piotr Bienkowski, Christopher Mee, and Elizabeth Slater 210 $aNew York $cT & T Clark$dc2005 215 $a1 online resource (320 p.) 225 1 $aLibrary of Hebrew Bible/Old Testament studies ;$v426 225 1 $aT & T Clark library of biblical studies 300 $aDescription based upon print version of record. 311 $a0-567-02691-4 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Abbreviations; List of Contributors; Migraines d'E?pigraphiste; Taima?' and Nabonidus: It's a Small World; Dresser le b?uf a? Ougarit; Literacy in an Oral Environment; Keilschrift versus Alphabetschrift: U?berlegungen zu den epigraphs auf Keilschrifttafeln; The Writing on the Wall: Law in Aramaic Epigraphy; 'Misspellings' in Cuneiform Alphabetic Texts from Ugarit: Some Cases of Loss or Addition of Signs; Some Uses of Writing in Ancient Israel in the Light of Recently Published Inscriptions 327 $aNow You See It, Now You Don't! The Monumental Use and Non-use of Writing in the Ancient Near EastWhat has Delphi to do with Samaria? Ambiguity and Delusion in Israelite Prophecy; Darius' Accession in (the) Media; 'Hazael, Son of a Nobody': Some Reflections in Light of Recent Study; 4Q341: An Exercise for Spelling and for Spells?; The Origins of the Inscribed Greek Stela; Only Fragments from the Past: The Role of Accident in our Knowledge of the Ancient Near East 330 $aThis book honors the significant and enduringwork of Old Testament scholar Alan Millard. The contributors to thisfestschrift take up all of his concerns with the relationship betweenwriting, the development and Israel, and ancient Near Eastern society. 410 0$aLibrary of Hebrew Bible/Old Testament studies ;$v426. 410 0$aT & T Clark library of biblical studies. 606 $aWriting$xHistory 607 $aMiddle East$xCivilization$yTo 622 615 0$aWriting$xHistory. 676 $a411/.09 701 $aBienkowski$b Piotr$0636855 701 $aMee$b C$g(Christopher)$0595683 701 $aMillard$b A. R$g(Alan Ralph)$0635376 701 $aSlater$b E. A$01489354 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782382603321 996 $aWriting and ancient Near Eastern society$93710035 997 $aUNINA