LEADER 02957nam 2200721Ia 450 001 9910782302803321 005 20230721033305.0 010 $a6611786147 010 $a1-281-78614-4 010 $a9786611786144 010 $a600-00-0631-4 010 $a1-60750-319-0 035 $a(CKB)1000000000553781 035 $a(EBL)363202 035 $a(OCoLC)437229108 035 $a(SSID)ssj0000290572 035 $a(PQKBManifestationID)11222134 035 $a(PQKBTitleCode)TC0000290572 035 $a(PQKBWorkID)10410464 035 $a(PQKB)10404470 035 $a(MiAaPQ)EBC363202 035 $a(Au-PeEL)EBL363202 035 $a(CaPaEBR)ebr10267467 035 $a(CaONFJC)MIL178614 035 $a(EXLCZ)991000000000553781 100 $a20080407d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBuilding and using datasets on armed conflicts$b[electronic resource] /$fedited by Mayeul Kauffmann 210 $aAmsterdam, Netherlands ;$aWashington, DC $cIOS Press$dc2008 215 $a1 online resource (204 p.) 225 0 $aNATO science for peace and security series. E, Human and societal dynamics ;$vv. 36 300 $aDescription based upon print version of record. 311 $a1-58603-847-8 320 $aIncludes bibliographical references and index. 327 $aTitle page; Preface; Foreword; Contents; Introduction; The Purposes of Conflict Dataset Building; Concept Definition and Data Building; Opening up Conflict Data; Author Index 330 $aThe so-called 'hard' or 'exact' sciences, with their necessary emphasis on technology and on the technical, are hardly reputed for being very human, and, conversely, the so-called 'human' sciences are often pronounced as 'soft' because they cannot be based on the certainties associated with the former. 410 0$aNATO Science for Peace and Security Series: Human and Societal Dynamics, v. 36 606 $aDatabases$vCongresses 606 $aPolitical violence$xDatabases$vCongresses 606 $aPolitical violence$xResearch$xStatistical methods$vCongresses 606 $aWar$xDatabases$vCongresses 606 $aWar$xResearch$xStatistical methods$vCongresses 610 1 $aArmed conflicts 615 0$aDatabases 615 0$aPolitical violence$xDatabases 615 0$aPolitical violence$xResearch$xStatistical methods 615 0$aWar$xDatabases 615 0$aWar$xResearch$xStatistical methods 676 $a327.16 701 $aKauffmann$b Mayeul$01473213 712 02$aNorth Atlantic Treaty Organization.$bPublic Diplomacy Division. 712 12$aNATO Advanced Research Workshop on Indicators and Databases for Risk Prevention 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782302803321 996 $aBuilding and using datasets on armed conflicts$93686274 997 $aUNINA LEADER 02628nam 22004093 450 001 9910158918903321 005 20250605080351.0 010 $a1-943772-44-4 035 $a(CKB)3710000001011621 035 $a(BIP)054729333 035 $a(MiAaPQ)EBC32132308 035 $a(Au-PeEL)EBL32132308 035 $a(OCoLC)959281038 035 $a(EXLCZ)993710000001011621 100 $a20250605d2015 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDukes Prefer Blondes 205 $a1st ed. 210 1$aNEW YORK :$cNancy Yost Literary Agency,$d2015. 210 4$d©2015. 215 $a1 online resource (384 p.) 225 1 $aThe Dressmakers Series ;$vv.4 330 8 $aLady Clara Fairfax--from Loretta Chase's New York Times bestselling Dressmakers series-- finds her own happily ever after in this sizzling, clever romance...Being an ornament to London's aristocratic society has its perks, but politely declining marriage proposals from gentlemen who see only her (admittedly inspiring) beauty, or equally inspiring dowry, is starting to wear on LCF. Her only escape is her favorite charity. When she learns that a child is in trouble, she turns to the expert on that subject: tall, dark and supremely annoying barrister, Oliver Radford.Radford is a barrister renowned for his brilliance and complete disregard for politeness and polite society; ironic, now that he finds himself in line to inherit a dukedom. Lady Clara is utterly lovely, and may not be entirely bereft of brains, but she isn't part of his plans, until she somehow overwhelms his own infallible logic. When wedlock looms, all he can do is try not to lose his head over her, unlike every other sapskull in London.It's an inconvenient marriage by ordinary standards, but the ton's most adored heiress and most difficult bachelor are far from ordinary. Has England's least likely couple fallen victim to their own unruly desires?"Queen of love and laughter Chase returns with a laugh-out-loud novel destined for the keeper shelf. There's hardly time to breathe between giggles and guffaws...The result is perfection." -Romantic Times, TOP PICK"One of the finest romance authors of all time." -Julia Quinn"Wickedly witty, warm, and engaging." -Stephanie Laurens 410 4$aThe Dressmakers Series 610 $aFiction 700 $aChase$b Loretta$01347788 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910158918903321 996 $aDukes Prefer Blondes$93586648 997 $aUNINA LEADER 06014nam 22007815 450 001 9910298273003321 005 20200705010904.0 010 $a3-642-31974-2 024 7 $a10.1007/978-3-642-31974-7 035 $a(CKB)3710000000315935 035 $a(EBL)1968261 035 $a(SSID)ssj0001407849 035 $a(PQKBManifestationID)11807638 035 $a(PQKBTitleCode)TC0001407849 035 $a(PQKBWorkID)11412293 035 $a(PQKB)11119112 035 $a(DE-He213)978-3-642-31974-7 035 $a(MiAaPQ)EBC1968261 035 $a(PPN)18315021X 035 $a(EXLCZ)993710000000315935 100 $a20141211d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEpigenetic Mechanisms in Cellular Reprogramming /$fedited by Alexander Meissner, Jörn Walter 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (244 p.) 225 1 $aEpigenetics and Human Health,$x2191-2262 300 $aDescription based upon print version of record. 311 $a3-642-31973-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface; Glossary; Contents; The Oocyte Determinants of Early Reprogramming; 1 Controversies Surrounding Oocyte Reprogramming; 2 A Brief History of SCNT; 3 The Uniqueness of the Oocyte: More than Totipotency; 4 Qualitative Aspects of Oocyte-Mediated Nuclear Reprogramming; 4.1 Characteristic Traits of the Oocyte Are Species Specific; 4.2 Transcriptional Activity in Germinal Vesicle-Stage Oocytes; 4.3 Different Maturation States and Accompanying Chromatin Configuration of Recipient Oocytes for SCNT; 5 Quantitative Aspects of Oocyte-Mediated Nuclear Reprogramming 327 $a5.1 Amount of Reprogramming Factors5.2 Kinetics of Reprogramming; 6 Gene Expression in Oocytes; 7 The Elusive Reprogramming Factors; 8 Using Transcriptomics and Proteomics to Search for the Molecular Fingerprint Indicative of an Oocyte´s Reprogramming Potenti...; 8.1 Candidate Gene Approach; 8.2 Transcriptome Analysis; 8.3 Proteome Analysis; Conclusion; References; Stella and Zygotic Reprogramming; 1 Stella; 1.1 Identification of Stella; 1.2 Expression Pattern of Stella; 1.3 Gene Disruption Analysis of Stella; 2 Epigenetic Reprogramming in Zygotes 327 $a2.1 Active Loss of 5mC in Zygotic Paternal Genome2.2 Protection of Imprinted Genes and Repetitive Sequences in Zygotes; 2.3 Involvement of 5hmC and Tet Proteins in Active Loss of 5mC; 2.4 Histone Modification in Zygotes; 3 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 3.1 Stella Protects Active Loss of 5mC in Zygotes; 3.2 Stella Protects Imprinted Genes and Repetitive Sequences; 3.3 Protective Function of Stella Depends on H3K9me2; 3.4 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 4 Perspectives; References; Histone Variants and Reprogramming in Early Development 327 $a1 Mammalian Development: Context and Early Epigenetic Reprogramming2 Mechanisms of Epigenetic Reprogramming and Chromatin Remodelling in the Early Embryo; 3 The Components of the Chromatin Change as Development Proceeds; 4 Histone Variants as Regulators of Epigenetic Information During Reprogramming; 5 H3.3 and De Novo Establishment of Heterochromatin; 6 H3 Variants: A Conserved Function in the Germline; 7 Variants of H2A: The Case of MacroH2A; 8 H2A.Z Shows a Dynamic Localisation During Early Reprogramming in Embryos 327 $a9 High Endogenous Levels of Phosphorylated H2A.X Are Characteristic of Early Embryos10 Barr Body-Deficient H2A: H2A.B; References; DNA Methylation Reprogramming in Preimplantation Development; 1 Epigenetic Profiles in Mature Gametes; 2 DNA Methylation Reprogramming in the Zygote; 3 The Mechanisms of DNA Demethylation; 4 DNA Methylation Reprogramming in Further Preimplantation Development; 5 Roles of Dnmts in Regulating DNA Methylation in Early Embryos; 5.1 Dnmt1; 5.2 Dnmt3a, Dnmt3L and Dnmt3b; 6 DNA Methylation Reprogramming in SCNT-Derived Embryos 327 $a7 Histone Modifications and DNA Methylation Crosstalk 330 $aThe ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field. 410 0$aEpigenetics and Human Health,$x2191-2262 606 $aHuman genetics 606 $aCytology 606 $aSystems biology 606 $aNucleic acids 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010 606 $aNucleic Acid Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14011 615 0$aHuman genetics. 615 0$aCytology. 615 0$aSystems biology. 615 0$aNucleic acids. 615 14$aHuman Genetics. 615 24$aCell Biology. 615 24$aSystems Biology. 615 24$aNucleic Acid Chemistry. 676 $a616.0277 702 $aMeissner$b Alexander$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWalter$b Jörn$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298273003321 996 $aEpigenetic Mechanisms in Cellular Reprogramming$92541194 997 $aUNINA