LEADER 05004nam 2200673Ia 450 001 9910782283203321 005 20230617040857.0 010 $a1-281-95608-2 010 $a9786611956080 010 $a981-279-669-X 035 $a(CKB)1000000000537895 035 $a(EBL)1681633 035 $a(OCoLC)815755899 035 $a(SSID)ssj0000201641 035 $a(PQKBManifestationID)11184391 035 $a(PQKBTitleCode)TC0000201641 035 $a(PQKBWorkID)10245481 035 $a(PQKB)10196587 035 $a(MiAaPQ)EBC1681633 035 $a(WSP)00005298 035 $a(Au-PeEL)EBL1681633 035 $a(CaPaEBR)ebr10255556 035 $a(EXLCZ)991000000000537895 100 $a20030721d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMetal ions and neurodegenerative disorders$b[electronic resource] /$feditor, Paolo Zatta 210 $aNew Jersey $cWorld Scientific$dc2003 215 $a1 online resource (538 p.) 300 $aDescription based upon print version of record. 311 $a981-238-398-0 320 $aIncludes bibliographical references and index. 327 $aContents ; Preface ; List of Contributors ; Chapter 1. Metal-Catalyzed Redox Activity in Neurodegenerative Disease ; 1. INTRODUCTION ; 1.1. Redox-Active Transition Metals in AD ; 1.2. Aggregation of Amyloid-B and Amyloid B Protein Precursor/Amyloid-p-Linked ROS Production 327 $a1.3. Iron in Neurodegenerative Disease 1.4. Iron-Mediated Oxidative Stress in Parkinson's Disease ; 1.5. Manganese and Parkinson's Disease ; 1.6. Antioxidant and Transition Metal Homeostasis ; 1.7. CuZnSOD Mutations and Familial Amyotrophic Lateral Sclerosis ; 2. CONCLUSIONS 327 $aChapter 2. Metals Distribution and Regionalization in the Brain 1. TRACE ELEMENT DISTRIBUTION IN NORMAL HUMAN BRAIN ; 1.1. Aluminum Iron Copper and Zinc Distribution in Normal Human Brain Sites in Relation to Age ; 1.2. Aluminum ; 1.3. Iron ; 1.4. Copper ; 1.5. Zinc 327 $a2. TRACE ELEMENT IMBALANCES IN NEURODEGENERATIVE DISEASES 2.1. Aluminum Iron Copper and Zinc in Alzheimer's Disease ; 2.2. Factors Affecting the Final Results ; 2.3. Aluminum Iron Copper and Zinc in Parkinson's Disease 327 $a2.4. Aluminum Iron Copper and Zinc in Western Pacific Parkinsonism-Dementia 2.5. Aluminum Iron Copper and Zinc in Amyotrophic Lateral Sclerosis ; 3. FINAL REMARKS ; Chapter 3. The Olfactory Pathway as a Route of Entry of Metals into the Brain ; 1. INTRODUCTION 327 $a2. ANATOMY OF THE OLFACTORY SYSTEM 330 $a Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences 606 $aMetal ions$xPhysiological effect 606 $aMolecular neurobiology 606 $aNervous system$xDegeneration 606 $aNeurotoxicology 615 0$aMetal ions$xPhysiological effect. 615 0$aMolecular neurobiology. 615 0$aNervous system$xDegeneration. 615 0$aNeurotoxicology. 676 $a616.80471 701 $aZatta$b Paolo$0307116 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782283203321 996 $aMetal ions and neurodegenerative disorders$93831366 997 $aUNINA