LEADER 03654nam 2200613Ia 450 001 9910782093203321 005 20200520144314.0 010 $a3-540-73930-0 024 7 $a10.1007/978-3-540-73930-2 035 $a(CKB)1000000000492398 035 $a(EBL)603424 035 $a(OCoLC)234238123 035 $a(SSID)ssj0000318310 035 $a(PQKBManifestationID)11923585 035 $a(PQKBTitleCode)TC0000318310 035 $a(PQKBWorkID)10310322 035 $a(PQKB)10166868 035 $a(DE-He213)978-3-540-73930-2 035 $a(MiAaPQ)EBC603424 035 $a(Au-PeEL)EBL603424 035 $a(CaPaEBR)ebr10230169 035 $a(CaONFJC)MIL135515 035 $a(PPN)123739373 035 $a(EXLCZ)991000000000492398 100 $a20080823d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aInnate immunity of plants, animals, and humans$b[electronic resource] /$fHolger Heine, editor 205 $a1st ed. 2008. 210 $aBerlin $cSpringer$dc2008 215 $a1 online resource (253 p.) 225 1 $aNucleic acids and molecular biology,$x0933-1891 ;$vv. 21 300 $aDescription based upon print version of record. 311 $a3-540-73929-7 320 $aIncludes bibliographical references and index. 327 $aEvolution of Resistance Genes in Plants -- The Path Less Explored: Innate Immune Reactions in Cnidarians -- Bug Versus Bug: Humoral Immune Responses in Drosophila melanogaster -- Cellular Immune Responses in Drosophila melanogaster -- Immune Reactions in the Vertebrates' Closest Relatives, the Urochordates -- Innate Immune System of the Zebrafish, Danio rerio -- Toll-Like Receptors in the Mammalian Innate Immune System -- NLRs: a Cytosolic Armory of Microbial Sensors Linked to Human Diseases -- Antimicrobial Peptides as First-Line Effector Molecules of the Human Innate Immune System -- The Complement System in Innate Immunity. 330 $aAll living organisms are in a constant battle against their environment. Since uncontained microorganisms would simply overgrow all higher animals, the evolution of multicellular organisms required adequate and efficient defense mechanisms to protect their own integrity and to ensure their own survival. These defense mechanisms, encompassing receptor proteins that sense the presence of pathogens and effector molecules that are involved in controlling them, are the elemental parts of the innate immune system. For many species, the innate immune system is the sole active defense system. Long thought to be an unspecific immune response, the discovery of the Toll-like receptors and their ligands finally revealed just how specific the innate immune response actually is. This book wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system. 410 0$aNucleic acids and molecular biology ;$vv. 21. 606 $aImmunity 606 $aNatural immunity 615 0$aImmunity. 615 0$aNatural immunity. 676 $a616.079 701 $aHeine$b Holger$01469256 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910782093203321 996 $aInnate immunity of plants, animals, and humans$93680682 997 $aUNINA