LEADER 03861oam 2200661I 450 001 9910781932503321 005 20230802004241.0 010 $a0-429-12723-5 010 $a1-283-34975-2 010 $a9786613349750 010 $a1-4200-0764-5 024 7 $a10.1201/b11175 035 $a(CKB)2550000000063354 035 $a(EBL)1446335 035 $a(SSID)ssj0000534949 035 $a(PQKBManifestationID)11359075 035 $a(PQKBTitleCode)TC0000534949 035 $a(PQKBWorkID)10520938 035 $a(PQKB)10056019 035 $a(MiAaPQ)EBC1446335 035 $a(Au-PeEL)EBL1446335 035 $a(CaPaEBR)ebr10508894 035 $a(CaONFJC)MIL334975 035 $a(OCoLC)899155931 035 $a(OCoLC)775570611 035 $a(EXLCZ)992550000000063354 100 $a20180420d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aChemistry of protein and nucleic acid cross-linking and conjugation /$fShan S. Wong, David M. Jameson 205 $a2nd ed. 210 1$aBoca Raton :$cCRC Press,$d2012. 215 $a1 online resource (608 p.) 300 $aRev. ed. of: Chemistry of protein conjugation and cross-linking. c1991. 311 $a0-8493-7491-X 320 $aIncludes bibliographical references. 327 $aFront Cover; Contents; Preface; Authors; Chapter 1: Overview of Protein Conjugation; Chapter 2: Review of Protein and Nucleic Acid Chemistry; Chapter 3: Reagents Targeted to Specific Functional Groups; Chapter 4: How to Design and Choose Cross-Linking Reagents; Homobifunctional Cross-Linking Reagents; Chapter 6: Heterobifunctional Cross-Linkers; Chapter 7: Multifunctional Cross-Linking Reagents; Chapter 8: Monofunctional and Zero -Length Cross -Linking Reagents; Chapter 9: General Approaches for Chemical Cross-Linking; Chapter 10: Analysis of Cross-Linked Products 327 $aChapter 11: Applications of Chemical Cross-Linking to the Study of Biological MacromoleculesChapter 12: Applications of Chemical Conjugation in the Preparation of Immunoconjugates and Immunogens; Chapter 13: Application of Chemical Conjugation for the Preparation of Immunotoxins and Other Drug Conjugates for Targeting Therapeutics; Chapter 14: Application of Chemical Conjugation to Solid-State Chemistry; Appendix A Amino Group-Directed Homobifunctional Cross-Linkers; Appendix B Sulfhydryl Group-Directed Homobifunctional Cross-Linkers 327 $aAppendix C Phenolate- and Imidazolyl-Group-Directed Reagents: Bisdiazonium PrecursorsAppendix D Group Selective Heterobifunctional Cross-Linkers; Appendix E Photoactivatable Heterobifunctional Cross-Linking Reagents; Back Cover 330 $aSince the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivit 606 $aProteins$xCrosslinking 606 $aNucleic acids$xStructure 615 0$aProteins$xCrosslinking. 615 0$aNucleic acids$xStructure. 676 $a572/.633 700 $aWong$b Shan S.$0951350 701 $aJameson$b David M$01527825 701 $aWong$b Shan S$0951350 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910781932503321 996 $aChemistry of protein and nucleic acid cross-linking and conjugation$93771063 997 $aUNINA