LEADER 03571oam 2200757M 450 001 9910781265003321 005 20211215042348.0 010 $a0-429-91879-8 010 $a0-429-90456-8 010 $a0-429-47979-4 010 $a1-283-07041-3 010 $a9786613070418 010 $a1-84940-619-7 024 7 $a10.4324/9780429479793 035 $a(CKB)2550000000032416 035 $a(EBL)690035 035 $a(OCoLC)723944310 035 $a(SSID)ssj0000525544 035 $a(PQKBManifestationID)11345915 035 $a(PQKBTitleCode)TC0000525544 035 $a(PQKBWorkID)10488990 035 $a(PQKB)10399421 035 $a(MiAaPQ)EBC690035 035 $a(Au-PeEL)EBL690035 035 $a(CaPaEBR)ebr10464076 035 $a(CaONFJC)MIL307041 035 $a(OCoLC)727944857 035 $a(OCoLC)212894181 035 $a(FINmELB)ELB148181 035 $a(OCoLC)1031872063 035 $a(OCoLC-P)1031872063 035 $a(FlBoTFG)9780429479793 035 $a(EXLCZ)992550000000032416 100 $a20180419d2018 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSearching to be Found $eUnderstanding and Helping Adopted and Looked After Children with Attention Difficulties /$fRandy Lee Comfort 205 $aFirst edition. 210 1$aLondon :$cTaylor and Francis,$d2018. 215 $a1 online resource (204 p.) 300 $aDescription based upon print version of record. 311 $a0-367-32674-4 311 $a1-85575-464-9 320 $aIncludes bibliographical references (p. 175-180) and index. 327 $aCOVER; CONTENTS; ACKNOWLEDGEMENTS; ABOUT THE AUTHOR; PREFACE; CHAPTER ONE The adopted/looked after child with attention difficulties; CHAPTER TWO Understanding the effects of maltreatment on early brain development and the consequences for ADHD/ADD and adopted/looked after children; CHAPTER THREE The ADHD/ADD adopted/looked after child at home and in the community; CHAPTER FOUR The ADHD/ADD adopted/looked after child at school; CHAPTER FIVE Social development in the ADHD/ADD adopted/looked after child; CHAPTER SIX Conclusions 327 $aAPPENDIX I Characteristics of Attention Deficit (Hyperactivity) DisorderAPPENDIX II ADHD/ADD adults who areadopted or who grew up in care; APPENDIX III Helpful suggestions for teachers and parents/carers; APPENDIX IV Resources; REFERENCES; INDEX 330 2 $a"A practical, supportive book for adoptive parents, carers, teachers and other professionals who live and work with families and children whose happiness and behaviours are affected by attention difficulties and hyperactivity. The examples of real children and adults in everyday situations translate research findings into meaningful strategies for helping families, teachers and children to find more successful means of managing difficult behaviours and emotions."--Provided by publisher. 517 3 $aHelping adopted and looked after children with attention difficulties 606 $aAttention-deficit-disordered children$xCare 606 $aAdopted children$xCare 606 $aFoster children$xCare 615 0$aAttention-deficit-disordered children$xCare. 615 0$aAdopted children$xCare. 615 0$aFoster children$xCare. 676 $a362.73 676 $a616.8589 700 $aLee Comfort$b Randy$01564260 801 0$bOCoLC-P 801 1$bOCoLC-P 906 $aBOOK 912 $a9910781265003321 996 $aSearching to be Found$93833224 997 $aUNINA LEADER 05281nam 22006374a 450 001 9910830224103321 005 20170815113943.0 010 $a1-281-13531-3 010 $a9786611135317 010 $a0-470-51743-3 010 $a0-470-51744-1 035 $a(CKB)1000000000413971 035 $a(EBL)326413 035 $a(OCoLC)476124182 035 $a(SSID)ssj0000176759 035 $a(PQKBManifestationID)11170150 035 $a(PQKBTitleCode)TC0000176759 035 $a(PQKBWorkID)10206033 035 $a(PQKB)10010364 035 $a(MiAaPQ)EBC326413 035 $a(PPN)188664904 035 $a(EXLCZ)991000000000413971 100 $a20070604d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIminosugars$b[electronic resource] $efrom synthesis to therapeutic applications /$feditors, Philippe Compain and Olivier R. Martin 210 $aChichester, West Sussex, England ;$aHoboken, NJ, USA $cJ. Wiley$dc2007 215 $a1 online resource (487 p.) 300 $aDescription based upon print version of record. 311 $a0-470-03391-6 320 $aIncludes bibliographical references and index. 327 $aIminosugars; Contents; Foreword; Preface; List of contributors; 1 Iminosugars: past, present and future; 2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications; 2.1 Introduction; 2.2 -Glucosidase inhibitors; 2.3 -Glucosidase inhibitors; 2.4 - and -Galactosidase inhibitors; 2.5 -Mannosidase inhibitors; 2.6 Concluding remarks and future prospects; References; 3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries; 3.1 Introduction; 3.2 Monocyclic compounds; 3.3 1-N-Iminosugars; 3.4 Bicyclic compounds 327 $a3.5 Other bicyclic compounds3.6 Iminosugar conjugates; 3.7 Conclusions; References; 4 Iminosugar C-glycosides: synthesis and biological activity; 4.1 Introduction; 4.2 Synthesis of iminosugar C-glycosides; 4.3 Biological activity of iminosugar C-glycosides; 4.4 Conclusion; References; 5 Imino-C-disaccharides and analogues: synthesis and biological activity; 5.1 Introduction; 5.2 Synthesis of imino-C-disaccharides; 5.3 Conformations of imino-C-disaccharides; 5.4 Glycosidase inhibitory activities of imino-C-disaccharides 327 $a5.5 Efficient combinatorial method for the discovery of glycosidase inhibitors5.6 Antitumour activity of new -mannosidase inhibitors; 5.7 Conclusion; References; 6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar-related glycosidase inhibitors; 6.1 Introduction; 6.2 1-Azasugars that are piperidines (isofagomine, noeuromycin, etc.); 6.3 1-Azasugars that are hydrazines; 6.4 1-Azasugars that are oxazines; 6.5 1-Azasugars that are piperidones; 6.6 Sulphur-containing analogues of 1-azasugars; 6.7 Slow inhibition and thermodynamics of binding 327 $a6.8 Are 1-azasugars (and iminosugars) transition state analogues?References; 7 Iminosugar-based glycosyltransferase inhibitors; 7.1 Biological role and structural features of glycosyltransferases; 7.2 Development of inhibitors of glycosyltransferases; 7.3 Conclusion; References; 8 Transition state analogue inhibitors of N-ribosyltransferases; 8.1 Introduction; 8.2 Nucleoside hydrolases; 8.3 Purine nucleoside phosphorylases (PNPs); 8.4 5'-Methylthioadenosine (MTA) nucleosidases and phosphorylases; 8.5 Ricin A-chain; References; 9 Iminosugars as antiviral agents; 9.1 Introduction 327 $a9.2 The relationship between glucosidase inhibition and antiviral action9.3 Fate of viral glycoproteins in glucosidase-inhibited cells; 9.4 Specificity of glucosidase inhibition; 9.5 N-Alkyl DNJs inhibit virus growth by non-glucosidase inhibitory mechanisms - other potential activities of these compounds; 9.6 New directions for improving glucosidase inhibitors as antiviral agents; References; 10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders; 10.1 Introduction; 10.2 Degradation of glycosphingolipids 327 $a10.3 Lysosomal enzyme biosynthesis and ER-associated degradation (ERAD) 330 $aIminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970's, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar 606 $aImino sugars$xSynthesis 606 $aImino sugars$xTherapeutic use 615 0$aImino sugars$xSynthesis. 615 0$aImino sugars$xTherapeutic use. 676 $a572.565 676 $a612/.01578 701 $aCompain$b Philippe$01663703 701 $aMartin$b Olivier R$01663704 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830224103321 996 $aIminosugars$94021215 997 $aUNINA