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010   $a9786612456251
010   $a92-4-068426-3
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035   $a(EBL)476144
035   $a(OCoLC)609852912
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100   $a20081027d2009      uf             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aPrinciples for modelling dose-response for the risk assessment of chemicals$b[electronic resource] /$ffirst draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals
210   $aGeneva, Switzerland $cWorld Health Organization$dc2009
215   $a1 online resource (163 p.)
225 1 $aEnvironmental health criteria,$x0250-863X ;$v239
300   $a"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
311   $a92-4-157239-6 
320   $aIncludes bibliographical references (p. 103-110).
327   $aCOVER; TITLE; COPYRIGHT; CONTENTS; NOTE TO READERS OF THE CRITERIA MONOGRAPHS; PREAMBLE; WHO PLANNING GROUP FOR THE IPCS HARMONIZATION PROJECT ON DOSE-RESPONSE MODELLING; WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA ON PRINCIPLES FOR MODELLING DOSE-RESPONSE FOR THE RISK ASSESSMENT OF CHEMICALS; PREFACE; ACRONYMS AND ABBREVIATIONS; 1. SUMMARY, CONCLUSIONS, AND RECOMMENDATIONS; 2. INTRODUCTION; 3. RISK ANALYSIS; 4. DOSE-RESPONSE MODELLING: BASIC CONCEPTS; 5. DOSE-RESPONSE MODELLING: WHY AND WHEN TO USE IT; 6. PRINCIPLES OF DOSE-RESPONSE MODELLING
327   $a7. COMMUNICATING THE RESULTS OF DOSE- RESPONSE MODELLING8. CONCLUSIONS AND RECOMMENDATIONS; REFERENCES; ANNEX 1: TERMINOLOGY; RESUME, CONCLUSIONS ET RECOMMANDATIONS; RESUMEN, CONCLUSIONES Y RECOMENDACIONES; THE ENVIRONMENTAL HEALTH CRITERIA SERIES
330   $aThis volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Programme on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationsh
410  0$aEnvironmental health criteria ;$v239.
606   $aDrugs$xDose-response relationship
606   $aRisk assessment
615  0$aDrugs$xDose-response relationship.
615  0$aRisk assessment.
676   $a363.172
712 02$aWorld Health Organization.
712 02$aUnited Nations Environment Programme.
712 02$aInternational Labour Organisation.
712 02$aInter-Organization Programme for the Sound Management of Chemicals.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910781055003321
996   $aPrinciples for modelling dose-response for the risk assessment of chemicals$93674979
997   $aUNINA