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010   $a9786611300395
010   $a0-309-11575-2
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100   $a19840919d1985      uy             0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 00$aDiseases of importance in the United States /$fby the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, Institute of Medicine
210   $aWashington, D.C. $cNational Academy Press$d1985
215   $a1 online resource (472 pages)
225 0 $aNew vaccine development : establishing priorities ;$vv. 1
300   $aPrepared for the National Institute of Allergy and Infectious Diseases.
311 0 $a0-309-03494-9 
320   $aIncludes bibliographical references and index.
327   $a""Title""; ""Copyright""; ""Acknowledgments""; ""Preface""; ""Abstract""; ""Contents""; ""1 Summary""; ""Selection of Candidates""; ""Determination of Health Benefits""; ""Disease Burden Estimates""; ""Infant Mortality Equivalence Values""; ""Total Disease Burden Values""; ""Vaccine Characteristics""; ""Predictions of Vaccine Development""; ""Definition of Probable Vaccine Target Population""; ""Estimation of Vaccine Utilization""; ""Estimation of Time to Licensure, Time to vaccine Adoption, and Delay of Vaccination Benefits: Discounting""; ""Estimation of vaccine Preventable Illness""
327   $a""Calculation of Expected Health Benefits for Each Vaccine"" ""Cost Calculations""; ""Calculation of Morbidity Costs Averted by the Vaccine""; ""Vaccination Program Costs""; ""Integration of Costs""; ""Interpretation of Health Benefit and Net Cost Rankings""; ""Findings, Conclusions, Recommendations""; ""Recommendation""; ""Reference""; ""2 Priority Setting for Health Related Investments: A Review of Methods""; ""Methods for Project Ranking and Selection""; ""Multiattribute Accounting""; ""Multiattribute Scoring""; ""Decision Analysis With Multiple Objectives""
327   $a""Cost-Effectiveness and Cost-Utility Analysis"" ""Benefit-Cost Analysis""; ""Selection of an Approach""; ""Issues in Project Ranking Methodologies""; ""Sources of Estimates""; ""Sequential or 'Lexicographic' Methods""; ""Interdependence Among Projects""; ""The 'Portfolio' Question""; ""Summary""; ""References""; ""3 Overview of the Analytic Approach""; ""Method""; ""Interpretation of Results""; ""Guidelines""; ""Definition of Dominance""; ""Step 1""; ""Step 2""; ""Step 3""; ""Step 4""; ""Summary""; ""4 Comparison of Disease Burdens and Costs""
327   $a""Elements of the System for Comparing Morbidity and Mortality Burdens Arising From various Diseases"" ""Trade-Off Values""; ""Expression of Morbidity and Mortality Burdens""; ""Procedures Used in Deriving Disease Estimates""; ""Limitations of the Current Estimates""; ""Value Judgments in Quantifying Morbidity and Mortality""; ""IME Perspectives used in This Study""; ""The Effect of Adopting Other IME Perspectives""; ""Comparison of Direct Costs Resulting from Diseases""; ""Scope of Cost Calculations""; ""Procedures""; ""Findings""; ""Limitations of the Proposed System""
327   $a""Summary and Conclusions"" ""Recommendations""; ""References""; ""5 Predictions on Vaccine Development""; ""The Need for Predictions""; ""Selection of Candidates""; ""Vaccine Candidates and Target Populations""; ""Predictions on Vaccine Development""; ""Probability of Successful Development""; ""Cost of Development""; ""Time to Licensure""; ""Comments""; ""Predictions on Vaccine Characteristics""; ""Efficacy""; ""Adverse Reactions""; ""Production Technology, Delivery Requirements, and Cost/Dose""; ""Number of Doses and Route of Administration""; ""Conclusions""; ""6 Assessing the Likely Utilization of New Vaccines""
606   $aVaccines$xResearch$xGovernment policy
606   $aVaccination$zUnited States
606   $aVaccination$zDeveloping countries
615  0$aVaccines$xResearch$xGovernment policy.
615  0$aVaccination
615  0$aVaccination
676   $a614.4/7/0973
712 02$aInstitute of Medicine (U.S.).$bCommittee on Issues and Priorities for New Vaccine Development.
712 02$aNational Institute of Allergy and Infectious Diseases (U.S.)
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912   $a9910780901103321
996   $aDiseases of importance in the United States$93717382
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