LEADER 05177nam 2200601 a 450 001 9910780890603321 005 20230721024410.0 010 $a9789814299350 (eBook) 035 $a(CKB)2490000000001778 035 $a(EBL)1681346 035 $a(OCoLC)729020965 035 $a(SSID)ssj0000441798 035 $a(PQKBManifestationID)12166733 035 $a(PQKBTitleCode)TC0000441798 035 $a(PQKBWorkID)10443820 035 $a(PQKB)10164036 035 $a(MiAaPQ)EBC1681346 035 $a(WSP)00000708 035 $a(Au-PeEL)EBL1681346 035 $a(CaPaEBR)ebr10422501 035 $a(EXLCZ)992490000000001778 100 $a20100924d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMedical applications of accelerators$b[electronic resource] /$feditors, Alexander W. Chao, Weiren Chou 210 $aSingapore $cWorld Scientific$d2009 215 $a1 online resource (320 p.) 225 0 $aReviews of accelerator science and technology ;$vv. 2, 2009 300 $aTwo columns to the page. 311 0 $a9789814299343 (Hardback) 320 $aIncludes bibliographical references. 327 $aContents; Editorial Preface; Physical and Biological Basis of Proton and of Carbon Ion Radiation Therapy and Clinical Outcome Data Herman Suit, Thomas F. Delaney and Alexei Trofimov; 1. Introduction; 2. Physics; 2.1. General considerations; 2.2. Need for gantries; 2.3. Penumbra; 2.4. Heterodensities in the beam path a narrow age range. The tumor(s) would be transplanted; 3. Radiation-Biological Considerations; 3.1. Slopes of dose-response curves; 3.2. LET and RBE; 3.3. RBE and dose; 3.4. OER; 4. Clinical Outcome Data; 4.1. Chordoma; 4.2. Chondrosarcoma; 4.3. Uveal melanoma; 4.4. Head and neck 327 $a4.5. Non-small-cell lung carcinoma4.6. Hepatocellular carcinoma; 4.7. Prostate carcinoma; 5. Discussion; Acknowledgments; References; The Production of Radionuclides for Radiotracers in Nuclear Medicine Thomas J. Ruth; 1. Introduction; 2. Radioisotope/Radionuclide Production; 2.1. Specific activity [1, 2]; 3. Accelerators; 3.1. Development of the linac; 3.1.1. Principles of operation; 3.1.2. Radio frequency acceleration; 3.1.3. Current linacs; 3.2. Development of the cyclotron; 3.2.1. Principles of cyclotron operation; 3.2.2. Energies and particles; 3.3. Choice of an accelerator 327 $a3.3.1. Comparison between cyclotrons and other accelerators [1]4. Medical Applications; 4.1. Historical background [2]; 4.2. Radionuclides for imaging; 4.3. Radionuclides for therapy; 4.4. Radioisotope production rates and yield considerations; 4.5. Generators; 5. Imaging; 5.1. Planar imaging; 5.2. Single photon emission computed tomography; 5.3. Positron emission tomography; 6. Functional Imaging; 7. Radiotracer and Chemistry Development; 7.1. Radiopharmaceuticals; 8. Future Directions; References 327 $aProton Radiation Therapy in the Hospital Environment: Conception, Development, and Operation of the Initial Hospital-Based Facility James M. Slater, Jerry D. Slater and Andrew J. Wroe1. Introduction; 2. Preparation Phase; 3. Developmental Phase; 3.1. Accelerator performance and maintenance; 4. Clinical Operations; 4.1. The central nervous system and the base of the skull (in adults): stereotactic radiosurgery; 4.2. Fractionated proton therapy for tumors of the central nervous system; 4.3. Diseases of the eye and tumors of the head and neck; 4.4. Lung, breast, and liver cancer 327 $a4.5. Cancer of the prostate4.6. Pediatric neoplasms; 4.7. Perspective; 5. Research Activities; 5.1. Research strategies; 5.1.1. Basic physics; 5.1.2. Modifying results of proton irradiation; 5.1.3. Engineering advances; 5.1.4. Protons for non-malignant diseases; 5.1.5. Space-science investigations; 5.2. Future directions; 6. Summary; References; Microwave Electron Linacs for Oncology David H. Whittum; 1. Introduction; 1.1. Why is an accelerator structure needed?; 1.2. How does an accelerator structure work?; 1.3. Circuit-equivalent model for a standing wave accelerator; 1.4. Cold test 327 $a1.5. Multicell accelerator structures 330 $aThe theme of this volume, "Medical Applications of Accelerators", is of enormous importance to human health and has a deep impact on our society. The invention of particle accelerators in the early 20th century created a whole new world for producing energetic X-rays, electrons, protons, neutrons and other particle beams. Immediately these beams found revolutionary applications in medicine. There are two important yet distinct medical applications. One is that accelerators produce radioisotopes for various nuclear medicines for millions of patients each year. The other is that accelerators p 606 $aParticle accelerators 615 0$aParticle accelerators. 676 $a539.73 701 $aChao$b Alex$0345495 701 $aChou$b Weiren$01502888 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910780890603321 996 $aMedical applications of accelerators$93787668 997 $aUNINA