LEADER 05385nam 2200637Ia 450 001 9910780816003321 005 20190510224449.0 010 $a1-282-38165-2 010 $a9786612381652 010 $a0-08-096516-4 035 $a(CKB)2550000000000897 035 $a(EBL)477371 035 $a(OCoLC)742296779 035 $a(SSID)ssj0000341866 035 $a(PQKBManifestationID)12134380 035 $a(PQKBTitleCode)TC0000341866 035 $a(PQKBWorkID)10396267 035 $a(PQKB)10449130 035 $a(MiAaPQ)EBC477371 035 $a(PPN)182566870 035 $a(EXLCZ)992550000000000897 100 $a19891018d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProgress in heterocyclic chemistry$hVolume 21$iCritical review of the 2006 literature preceded by two chapters on current heterocyclic topics$b[electronic resource] /$feditors, Gordon W. Gribble and John A. Joule 210 $aOxford ;$aNew York $cPergamon Press$d2009 215 $a1 online resource (573 p.) 225 0 $aProgress in heterocyclic chemistry ;$v21 300 $aDescription based upon print version of record. 311 $a0-08-096515-6 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Progress in Heterocyclic Chemistry; Copyright Page; Contents; Foreword; Chapter 1 Biocatalytic Approaches to Chiral Heterocycles; 1.1 Introduction; 1.2 Enzyme classes discussed; 1.3 Three-membered ring systems; 1.4. Four-membered ring systems; 1.5 Five-membered ring systems; 1.6 Six-membered ring systems; 1.7 Seven-membered and larger ring systems; 1.8 Conclusion; 1.9 References; Chapter 2 Ring-Expanded ('fat') Purines and their Nucleoside/ Nucleotide Analogues as Broad-Spectrum Therapeutics; 2.1 Introduction 327 $a2.2 Significance of 'fat' purines and their nucleoside/nucleotide analogues2.3 Chemistry; 2.4 Biochemical and biophysical chemistry; 2.5 Biological activity; 2.6 Conclusion; 2.7 Acknowledgments; 2.8 References; Chapter 3 Three-Membered Ring Systems; 3.1 Introduction; 3.2 Epoxides; 3.3 Aziridines; 3.4 References; Chapter 4 Four-Membered Ring Systems; 4.1 Introduction; 4.2 Azetidines, azetines, and related systems; 4.3 Monocyclic 2-azetidinones (ß-lactams); 4.4 Fused and spirocyclic ß-lactams; 4.5 Oxetanes, dioxetanes, oxetanediones and 2-oxetanones ( ß-lactones) 327 $a4.6 Thietanes, ß-sultams, and related systems4.7 Silicon and phosphorus heterocycles. Miscellaneous; 4.8 References; Chapter 5.1 Five-Membered Ring Systems: Thiophenes and Se/Te Analogues; 5.1.1 Introduction; 5.1.2 Thiophene ring synthesis; 5.1.3 Reactions of thiophenes; 5.1.4 Non-polymeric thiophene organic materials; 5.1.5 Thiophene oligomers and polymers; 5.1.6 Thiophene derivatives in medicinal chemistry; 5.1.7 Selenophenes and tellurophenes; 5.1.8 References; Chapter 5.2 Five-Membered Ring Systems: Pyrroles and Benzo Analogs; 5.2.1 Introduction; 5.2.2 Synthesis of pyrroles 327 $a5.2.3 Reactions of pyrroles5.2.4 Pyrrole natural products and materials; 5.2.5 Synthesis of indoles; 5.2.6 Reactions of indoles; 5.2.7 Indole natural products; 5.2.8 Oxindoles and spirooxindoles; 5.2.9 Carbazoles; 5.2.10 Azaindoles and carbolines; 5.2.11 Bioorganic chemistry; 5.2.12 References; Chapter 5.3 Five-Membered Ring Systems: Furans and Benzofurans; 5.3.1 Introduction; 5.3.2 Reactions; 5.3.3 Synthesis; 5.3.4 References; Chapter 5.4 Five Membered Ring Systems: With More than One N Atom; 5.4.1 Introduction; 5.4.2 Pyrazoles and ring-fused derivatives 327 $a5.4.3 Imidazoles and ring-fused derivatives5.4.4 1,2,3-Triazoles and ring-fused derivatives; 5.4.5 1,2,4-Triazoles and ring-fused derivatives; 5.4.6 Tetrazoles and ring-fused derivatives; 5.4.7 References; Chapter 5.5 Five-Membered Ring Systems: With N and S (Se) Atoms; 5.5.1 Introduction; 5.5.2 Thiazoles; 5.5.3 Isothiazoles; 5.5.4 Thiadiazoles and selenodiazoles; 5.5.5 1,3-Selenazoles, 1,3-selenadolidines and 1,3-tellurazoles; 5.5.6 References; Chapter 5.6 Five-Membered Ring Systems: With O & S (Se, Te) Atoms; 5.6.1 1,3-Dioxoles and dioxolanes; 5.6.2 1,3-Dithioles and dithiolanes 327 $a5.6.3 1,3-Oxathioles and oxathiolanes 330 $aProgress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 21 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review ""Biocatalytic approaches to chiral heterocycles"" and ""Ring-e 410 0$aProgress in Heterocyclic Chemistry 606 $aHeterocyclic chemistry 606 $aHeterocyclic compounds 615 0$aHeterocyclic chemistry. 615 0$aHeterocyclic compounds. 676 $a547.59 701 $aGribble$b Gordon W$093007 701 $aJoule$b J. A$g(John Arthur)$091644 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910780816003321 996 $aProgress in heterocyclic chemistry$93825671 997 $aUNINA