LEADER 04507nam 2200385z- 450 001 9910220057803321 005 20231214132945.0 035 $a(CKB)3800000000216200 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42240 035 $a(EXLCZ)993800000000216200 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiology of Cognitive Aging: Model Systems, Technologies and Beyond 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (145 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-144-5 330 $aWelcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer?s disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves ?old? memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer?s disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves ?old? memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D. 517 $aBiology of Cognitive Aging 610 $aParkinson's disease 610 $aoutreach 610 $aage-related memory impairment 610 $aSemi-automated system 610 $aAlzheimer's disease 610 $aPatients 610 $aDementia 700 $aShin Murakami$4auth$01287787 906 $aBOOK 912 $a9910220057803321 996 $aBiology of Cognitive Aging: Model Systems, Technologies and Beyond$93020389 997 $aUNINA LEADER 02269nam 2200637 a 450 001 9910780768303321 005 20200520144314.0 010 $a0-8132-1660-5 035 $a(CKB)2440000000013956 035 $a(OCoLC)301217194 035 $a(CaPaEBR)ebrary10282775 035 $a(SSID)ssj0000487038 035 $a(PQKBManifestationID)11293648 035 $a(PQKBTitleCode)TC0000487038 035 $a(PQKBWorkID)10442502 035 $a(PQKB)10220898 035 $a(MdBmJHUP)muse24290 035 $a(Au-PeEL)EBL3134778 035 $a(CaPaEBR)ebr10282775 035 $a(OCoLC)922996462 035 $a(MiAaPQ)EBC3134778 035 $a(EXLCZ)992440000000013956 100 $a20030403d2004 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRepresenting the troubles in Irish short fiction$b[electronic resource] /$fMichael L. Storey 210 $aWashington, D.C. $cCatholic University of America Press$dc2004 215 $a1 online resource (257 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-8132-1366-5 320 $aIncludes bibliographical references (p. 229-235) and index. 606 $aEnglish fiction$xIrish authors$xHistory and criticism 606 $aShort stories, English$xHistory and criticism 606 $aNationalism and literature$zIreland$xHistory$y20th century 606 $aPolitics and literature$zIreland$xHistory$y20th century 606 $aLiterature and society$zIreland$xHistory$y20th century 606 $aRomanticism$zIreland$xHistory$y20th century 607 $aIreland$xIn literature 615 0$aEnglish fiction$xIrish authors$xHistory and criticism. 615 0$aShort stories, English$xHistory and criticism. 615 0$aNationalism and literature$xHistory 615 0$aPolitics and literature$xHistory 615 0$aLiterature and society$xHistory 615 0$aRomanticism$xHistory 676 $a823/.0109358 700 $aStorey$b Michael L.$f1942-$01556081 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910780768303321 996 $aRepresenting the troubles in Irish short fiction$93818506 997 $aUNINA