LEADER 05818nam 22007814a 450 001 9910780468403321 005 20230417220839.0 010 $a1-280-50567-2 010 $a9786610505678 010 $a600-00-0589-X 010 $a1-60129-472-7 035 $a(CKB)111087028238676 035 $a(EBL)267542 035 $a(OCoLC)228124762 035 $a(SSID)ssj0000258741 035 $a(PQKBManifestationID)11204431 035 $a(PQKBTitleCode)TC0000258741 035 $a(PQKBWorkID)10256899 035 $a(PQKB)10263034 035 $a(MiAaPQ)EBC267542 035 $a(Au-PeEL)EBL267542 035 $a(CaPaEBR)ebr10116447 035 $a(CaONFJC)MIL50567 035 $a(EXLCZ)99111087028238676 100 $a20020820d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThiol metabolism and redox regulation of cellular functions /$f[edited by] Alfonso Pompella, Gabor Banhegyi, Maria Wellman-Rousseau 210 1$aAmsterdam ;$aWashington, DC :$cIOS Press,$d2002. 215 $a1 online resource (365 pages) $cillustrations 225 1 $aNATO science series. Series I, Life and behavioural sciences,$x1566-7693 ;$vv. 347 300 $a"Published in cooperation with NATO Scientific Affairs Division." 300 $a"Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy"--T.p. verso. 311 0 $a0-585-45870-7 311 0 $a1-58603-282-8 320 $aIncludes bibliographical references and index. 327 $aCover; Title page; Foreword; Preface; Contributors; Contents; Oxidative Signaling and Glutathione Synthesis; Cell Survival and Changes in Gene Expression in Cells Unable to Synthesize Glutathione; Role of Glutathione in the Regulation of Liver Metabolism; Glutathione Transport in the Endo/Sarcoplasmic Reticulum; Role of Ascorbate in Oxidative Protein Folding; Cytophotometric Investigations on Oscillating Thiol-Disulfide Equilibria and Oxidized Protein Sulfur; Protection by Pantothenic Acid against Apoptosis and Cell Damage by Oxygen Free Radicals - The Role of Glutathione 327 $aThiols as Major Determinants of the Total Antioxidant Capacity; Enzymes of the Thiol-dependent Hydroperoxide Metabolism in Pathogens as Potential Drug Targets; Is there a Role of Glutathione Peroxidases in Signaling and Differentiation?; Multidrug Resistance-associated Proteins: Export Pumps for Conjugates with Glutathione, Glucuronate or Sulfate; Detoxification of Electrophilic Compounds by Glutathione S-Transferase Catalysis: Determinants of Individual Response to Chemical Carcinogens and...; Transcriptional Regulation of Glutathione S-Transferase P1-1 in Human Leukemia 327 $aMechanism of ?-Glutamyltranspeptidase Folding and Activation in the Endoplasmic Reticulum; The Role of ?-Glutamyl Transpeptidase in the Biosynthesis of Glutathione; Role of ?-Glutamyltransferase in the Homeostasis of Glutathione during Oxidative and Nitrosative Stress; The Importance of gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense; The Role of gamma-Glutamyltranspeptidase in the Metabolism and Cytotoxicity of 4-Hydroxynonenal-Glutathione Conjugate: Evidence and Hypothesis; ?-Glutamyltransferase-Dependent Prooxidant Reactions: a Factor in Multiple Processes 327 $aSerum gamma-Glutamyl Transpeptidase: a Prognostic Marker in Cardiovascular Diseases; Lipoic Acid: a Multifunctional Antioxidant; Is Glutathione an Important Neuroprotective Effector Molecule against Amyloid Beta Toxicity?; Antioxidants in Cancer Therapy: is there a Rationale to Recommend Antioxidants during Cancer Therapy?; Disulfide Exchange in CD4; Redox Regulation in Protein Folding and Chaperone Function; Reduction of the Endoplasmic Reticulum Accompanies the Oxidative Damage of Diabetes Mellitus; Analytical Developments in the Assay of Intra- and Extracellular GSH Homeostasis 327 $aSignalling Potential and Protein Modifying Ability of Physiological Thiols; Redox Signaling and the Map Kinase Pathways; Redox Regulation of Mitochondrial Permeability Transition: Contrasting Effects of Lipoic Acid and its Positively Charged Analog LA-Plus; Redox State of Glutathione and Thioredoxin in Differentiation and Apoptosis; Redox Regulation of DNA Repair; Author Index 330 $aThis volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place. 410 0$aNATO science series.$nSeries I,$pLife and behavioural sciences ;$v347. 606 $aAntioxidants$vCongresses 606 $aThiols$xPhysiological effect$vCongresses 606 $aGlutathione$xPhysiological effect$vCongresses 606 $aOxidation-reduction reaction$vCongresses 606 $aCell respiration$vCongresses 615 0$aAntioxidants 615 0$aThiols$xPhysiological effect 615 0$aGlutathione$xPhysiological effect 615 0$aOxidation-reduction reaction 615 0$aCell respiration 676 $a572.7 701 $aPompella$b Alfonso$01488513 701 $aBa?nhegyi$b Ga?bor$01488514 701 $aWellman-Rousseau$b Maria$01488515 712 12$aNATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions$f(2002 :$ePisa, Italy) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910780468403321 996 $aThiol metabolism and redox regulation of cellular functions$93708766 997 $aUNINA