LEADER 04932oam 2200481 450 001 9910779978103321 005 20190911100030.0 010 $a0-12-405535-4 035 $a(OCoLC)881097145 035 $a(MiFhGG)GVRL8CUA 035 $a(EXLCZ)992550000001108357 100 $a20140319d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aAutophagy $ecancer, other pathologies, inflammation, immunity, infection, and aging. Volume 1 /$fedited by M.A. Hayat 210 $aSan Diego, Calif. $cAcademic Press$dc2014 210 1$aSan Diego, CA :$cAcademic Press,$d2014. 215 $a1 online resource (xxix, 329 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a0-12-405530-3 311 $a1-299-77456-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging; Copyright Page; Dedication; Contents; Preface; Contributors; List of Contributions Projected in Volumes 2-4; Abbreviations and Glossary; 1 Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4; Introduction; Specific Functions of Autophagy (A Summary); Autophagy in Normal Mammalian Cells; Major Types of Autophagies; Macroautophagy (Autophagy); Microautophagy; Chaperone-Mediated Autophagy; Selective Autophagies; Autophagosome Formation 327 $aAutophagic Lysosome ReformationAutophagic Proteins; Protein Degradation Systems; Beclin 1; Non-Autophagic Function of Autophagy-Related Proteins; Microtubule-Associated Protein Light Chain 3; Monitoring Autophagy; Reactive Oxygen Species (ROS); Mammalian Target of Rapamycin (mTOR); Role of Autophagy in Tumorigenesis and Cancer; Role of Autophagy in Immunity; Role of Autophagy in Viral Defense and Replication; Role of Autophagy in Intracellular Bacterial Infection; Role of Autophagy in Heart Disease; Role of Autophagy in Neurodegenerative Diseases; Cross-Talk between Autophagy and Apoptosis 327 $aReferencesI General Diseases; 2 Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases; Introduction; LC3 Recognition by p62; Interacting Region between LC3 and p62; Overall Structure of the LC3-p62-LRS Complex; Characterization of Atg8 Homologue-LRS Domain; Role of p62 as an Autophagy Receptor; Autophagic Degradation of p62; Requirement of the PB1 Domain for p62 Degradation; Ubiquitin- and p62-Positive Inclusion Formation; Discussion; References; 3 Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases; Autophagy Overview and Types 327 $aPathway and Mechanism for AutophagyInitiation; Nucleation; Elongation; Maturation/Fusion with Lysosomes; Physiological Roles of Autophagy; Autophagy and Neuronal Physiology; Quality Control; Development and Differentiation; Autophagy and Neurodegenerative Diseases; Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Cerebral Ischemia (Injury); Conclusions and Future Perspective; Acknowledgments; References; 4 Roles of Multiple Types of Autophagy in Neurodegenerative Diseases 327 $aDegradation of ALS-Linked Mutant SOD1 by MacroautophagyInteraction between Parkinson's Disease-Associated UCH-L1 and Chaperone-Mediated Autophagy; Degradation of RNA by Rnautophagy: Its Possible Roles in Neurodegenerative Disorders; References; 5 Autophagy and Crohn's Disease: Towards New Therapeutic Connections; Introduction: Crohn's Disease and Faulty Autophagy go Hand in Hand; Autophagy: A Hot Novel Target or an Old Friend?; Autophagy Regulates Immunity; Anti-TNF-?; Thiopurines; Curcumin; Direct Autophagy Modulators; Diagnostic Value of the Autophagic Status; Concluding Remarks; References 327 $a6 The Role of Autophagy in Atherosclerosis 330 $a Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, ma 606 $aAutophagic vacuoles 615 0$aAutophagic vacuoles. 676 $a616.079 702 $aHayat$b M. A.$f1940- 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910779978103321 996 $aAutophagy$9230705 997 $aUNINA