LEADER 03164nam 2200613 a 450 001 9910779738203321 005 20230725061551.0 010 $a3-11-032248-X 024 7 $a10.1515/9783110322484 035 $a(CKB)2550000001096918 035 $a(EBL)1195529 035 $a(OCoLC)851970842 035 $a(SSID)ssj0000801489 035 $a(PQKBManifestationID)11508637 035 $a(PQKBTitleCode)TC0000801489 035 $a(PQKBWorkID)10774491 035 $a(PQKB)11763160 035 $a(MiAaPQ)EBC1195529 035 $a(DE-B1597)210962 035 $a(OCoLC)1013957460 035 $a(OCoLC)853248961 035 $a(DE-B1597)9783110322484 035 $a(Au-PeEL)EBL1195529 035 $a(CaPaEBR)ebr10728639 035 $a(CaONFJC)MIL503452 035 $a(EXLCZ)992550000001096918 100 $a20130709d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aOn determining what there is$b[electronic resource] $ethe identity of ontological categories in Aquinas, Scotus and Lowe /$fPaul Symington 210 $aFrankfurt $cOntos Verlag$d2010 215 $a1 online resource (183 p.) 225 1 $aEIDE : foundations of ontology ;$vv. 2 300 $aDescription based upon print version of record. 311 $a3-11-032218-8 311 $a1-299-72201-6 320 $aIncludes bibliographical references. 327 $t Frontmatter -- $tTABLE OF CONTENTS -- $tACKNOWLEDGEMENTS -- $tINTRODUCTION -- $tCHAPTER ONE: AQUINAS ON ESTABLISHING THE IDENTITY OF ARISTOTLE'S CATEGORIES -- $tCHAPTER TWO: SCOTUS'S CRITICISM OF AQUINAS'S DERIVATION OF THE CATEGORIES -- $tCHAPTER THREE: A RECONSIDERATION AND DEFENSE OF AQUINAS'S POSITION -- $tCHAPTER FOUR: LOGICAL SYNTAX AND LOWE'S FOUR-CATEGORY ONTOLOGY -- $tCONCLUSION -- $tWORKS CITED -- $t Backmatter 330 $aGenerally, categories are understood to express the most general features of reality. Yet, since categories have this special status, obtaining a correct list of them is difficult. This question is addressed by examining how Thomas Aquinas establishes the list of categories through a technique of identifying diversity in how predicates are per se related to their subjects. A sophisticated critique by Duns Scotus of this position is also examined, a rejection which is fundamentally grounded in the idea that no real distinction can be made from a logical one. It is argued Aquinas's approach can be rehabilitated in that real distinctions are possible when specifically considering per se modes of predication. This discussion between Aquinas and Scotus bears fruit in a contemporary context insofar as it bears upon, strengthens, and seeks to correct E. J. Lowe's four-category ontology view regarding the identity and relation of the categories. 410 0$aEide ;$vv. 2. 606 $aOntology 615 0$aOntology. 676 $a230.6 700 $aSymington$b Paul$01499450 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910779738203321 996 $aOn determining what there is$93725478 997 $aUNINA LEADER 04629nam 22007095 450 001 9910896194103321 005 20250808085432.0 010 $a3-031-68730-2 024 7 $a10.1007/978-3-031-68730-3 035 $a(MiAaPQ)EBC31708169 035 $a(Au-PeEL)EBL31708169 035 $a(CKB)36292758600041 035 $a(DE-He213)978-3-031-68730-3 035 $a(EXLCZ)9936292758600041 100 $a20241005d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGene Regulation and Epigenetics $eHow Science Works /$fby Carsten Carlberg 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (268 pages) 311 08$a3-031-68729-9 327 $a1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: nuclear receptors -- 6. Genome-wide principles of gene regulation -- 7. DNA methylation -- 8. Histone modifications -- 9. Chromatin remodeling and organization -- 9. Regulatory impact of ncRNA -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and immunity -- 14. Epigenetics and disease -- 15. Cancer epigenetics -- 16. Nutritional epigenetics. 330 $aThis book delves into the fascinating realm of eukaryotic gene regulation. The specific expression of genes shapes the phenotype of cells and tissues. The regulation of gene expression, including up- and downregulation, is a fundamental aspect of nearly all physiological processes, both in health and disease. These dynamic processes respond to various daily challenges, such as dietary changes and infections. Therefore, it is crucial for not only biologists and biochemists but also all students in biomedical disciplines to understand gene regulation concepts. This foundational knowledge will benefit them in their specialized fields. A comprehensive understanding of transcription factors and the mechanisms that alter their activity is a fundamental goal of modern life science research. Epigenetics refers to the packaging and accessibility of the genome in each of the trillions of cells in our bodies. The prefix ?epi? (meaning ?upon,? ?above,? or ?beyond?) indicates that epigenetic processes do not alter the DNA sequence of our genome, adding a layer of information beyond that encoded in our genome. Genomic DNA is wrapped around complexes of histone proteins, helping it fit into a cell nucleus with a diameter of less than 10 ?m. This protein-DNA complex is known as chromatin. The content of this book is linked to the ?Molecular Medicine and Genetics? course, which the author has lectured on in various forms since 2002 at the University of Eastern Finland in Kuopio. This book is an updated version of the textbooks ?Mechanisms of Gene Regulation? and ?Human Epigenomics.? It is divided into 16 chapters. Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA. Three chapters then discuss the impact of epigenetics from a health perspective, and the final three chapters address epigenetics from the perspective of diseases. A glossary in the appendix explains the major specialist terms. 606 $aMolecular biology 606 $aGenetic transcription 606 $aEpigenetics 606 $aGenomics 606 $aMolecular genetics 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMolecular Biology 606 $aGene Transcription 606 $aEpigenetics 606 $aGenomics 606 $aMolecular Genetics 606 $aBiomedical Research 615 0$aMolecular biology. 615 0$aGenetic transcription. 615 0$aEpigenetics. 615 0$aGenomics. 615 0$aMolecular genetics. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aMolecular Biology. 615 24$aGene Transcription. 615 24$aEpigenetics. 615 24$aGenomics. 615 24$aMolecular Genetics. 615 24$aBiomedical Research. 676 $a572 700 $aCarlberg$b Carsten$0849346 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910896194103321 996 $aGene Regulation and Epigenetics$94214580 997 $aUNINA