LEADER 04860oam 2200505 450 001 9910779691003321 005 20190911112724.0 010 $a1-299-46292-8 010 $a1-84816-837-3 035 $a(OCoLC)841461183 035 $a(MiFhGG)GVRL8QYP 035 $a(EXLCZ)992550000001019212 100 $a20130828h20132013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 14$aThe neutrophils $enew outlook for old cells /$feditor, Dmitry Gabrilovich, H. Lee Moffitt Cancer Center, USA, University of South Florida, USA 205 $a3rd ed. 210 $aLondon $cImperial College Press ;$aSingapore ;$aHackensack, NJ $cDistributed by World Scientific Pub.$dc2013 210 1$aLondon :$cImperial College Press,$d[2013] 210 4$d?2013 215 $a1 online resource (xxiii, 422 pages) $cillustrations (some color) 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a1-84816-836-5 320 $aIncludes bibliographical references and index. 327 $aList of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation - Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF) 327 $a1.3.2.1 PU.1 - Generation of CMP from HSC1.3.2.2 C/EBP? - Generation of GMP from CMP; 1.3.2.3 C/EBP? - Terminal stages of differentiation; 1.3.2.4 Gfi-1 - Terminal stages of differentiation; 1.3.2.5 Other transcription factors important for granulopoiesis; 1.3.2.5.1 Retinoic acid receptors; 1.3.2.5.2 HoxA10; 1.3.2.5.3 LEF-1; 1.3.3 MicroRNA; 1.3.4 Cell cycle regulation; 1.4 Emergency Granulopoiesis; 1.5 Conclusion; References; Chapter 2: The Neutrophil Respiratory Burst Oxidase Mark T. Quinn; 2.1 Introduction; 2.2 NADPH Oxidase Components; 2.2.1 Flavocytochrome b; 2.2.2 p47phox; 2.2.3 p67phox 327 $a2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2 -); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen ( 1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO-); 2.7 Summary; Acknowledgments; References 327 $aChapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); References 327 $aChapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions 327 $a4.5.5 PECAM-1 330 $aThis is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of 606 $aNeutrophils 615 0$aNeutrophils. 676 $a571.96 702 $aGabrilovich$b Dmitry I. 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910779691003321 996 $aThe neutrophils$93870717 997 $aUNINA