LEADER 04050nam  2200565Ia 450 
001 9910779384203321
005 20230721020800.0
035   $a(CKB)2550000000110222
035   $a(EBL)3382867
035   $a(SSID)ssj0000882588
035   $a(PQKBManifestationID)11471859
035   $a(PQKBTitleCode)TC0000882588
035   $a(PQKBWorkID)10915439
035   $a(PQKB)11317679
035   $a(OCoLC)802052274
035   $a(MiAaPQ)EBC3382867
035   $a(Au-PeEL)EBL3382867
035   $a(CaPaEBR)ebr10567939
035   $a(OCoLC)923313122
035   $a(EXLCZ)992550000000110222
100   $a20150414d2007      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aAnalysis, occurrence, and toxicity of c-methylaminoalanine (BMAA)$b[electronic resource] $ea risk for the consumer?
210   $aCopenhagen $cNordic Council of Ministers$dc2007
215   $a1 online resource (131 p.)
225  0$aTemaNord ;$v2007:561
300   $aAt head of title: Norden.
311   $a92-893-1541-5 
320   $aIncludes bibliographical references.
327   $a""Content""; ""Preface""; ""Summary in English""; "" 1. Introduction""; "" 2. A historical perspective on the link between BMAA exposure and degenerative neurological disease""; ""2.1 Conclusions on cycad and BMAA exposure and degenerative neurological disease""; ""3. Case reports on animals, toxicological studies on cycad materials and preparations ""; ""3.1 Case reports on animals""; ""3.2 Studies on primates fed preparations from Cycas circinalis""; ""3.3 Studies on rodents fed preparations from Cycas circinalis""; ""3.4 Rodent studies on other cycad species than C. circinalis""
327   $a""3.5 Conclusions on case reports and toxicological studies performed with cycad preparations. """"4. BMAA as a natural toxicant in cycads and studies on BMAA toxicity""; ""4.1 Biosynthesis""; ""4.2 Effects in plants a??? a possible mechanism of action""; ""4.3 Toxicokinetics""; ""4.4 In vivo studies ""; ""4.5 Studies on infusion of BMAA directly into brain or brain ventricles""; ""4.6 In vitro studies ""; ""4.7 Conclusions on BMAA as a natural toxicant in cycads and on studies of BMAA toxicity""; ""5. Identity and physical and chemical properties of BMAA, and its chemical analysis""
327   $a""5.1 Identity """"5.2 Physical and chemical properties""; ""5.3 Carbamates""; ""5.4 Bound BMAA""; ""5.5 Methods of analysis""; ""5.6 Development of an LC-MS/MS method and analysis of BMAA in cycads and cyanobacteria""; ""5.7 Analysis of cyanobacteria with HPLC and the ninhydrin reaction""; "" 5.8 Conclusion on physical and chemical properties of BMAA and methods of analysis""; ""6. Occurrence of BMAA i cycads""; ""6.1 Cycad plants from the genus Cycas""; ""6.2 Cycad flour""; ""6.3 Conclusions on occurrence of BMAA in cycads""
327   $a""7. The theory of biomagnification and identification of BMAA in human tissues""""7.1 Flying foxes""; ""7.2 Brain material and other tissues from control individuals and patients with degenerative neurological disease""; ""7.3 Conclusion on the theory of biomagnification of BMAA and identification of BMAA in human tissues""; ""8. Is BMAA produced by cyanobacteria ""; ""Conclusion on possible production of BMAA by cyanobacteria""; ""9. Conclusions""; ""10. Recommendations""; "" Sammanfattning  (Summary in Swedish)""; "" 11. References""; "" Annex 1""; ""Summaries of epidemiological studies""
327   $a""Annex 2""""Table 1. In vivo studies on cycad preparations""; "" Table 2. In vivo studies on BMAA.""
606   $aAmino acids$xToxicology
606   $aNeurotoxic agents
615  0$aAmino acids$xToxicology.
615  0$aNeurotoxic agents.
712 02$aNordic Council of Ministers.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910779384203321
996   $aAnalysis, occurrence, and toxicity of c-methylaminoalanine (BMAA)$93777130
997   $aUNINA