LEADER 03413nam 2200601Ia 450 001 9910779233003321 005 20230721020721.0 010 $a0-19-176873-1 010 $a1-283-57977-4 010 $a9786613892225 010 $a0-19-157532-1 035 $a(CKB)2550000000105396 035 $a(EBL)975667 035 $a(OCoLC)801363491 035 $a(SSID)ssj0000692058 035 $a(PQKBManifestationID)11363258 035 $a(PQKBTitleCode)TC0000692058 035 $a(PQKBWorkID)10634917 035 $a(PQKB)11649804 035 $a(StDuBDS)EDZ0000128746 035 $a(MiAaPQ)EBC975667 035 $a(Au-PeEL)EBL975667 035 $a(CaPaEBR)ebr10581387 035 $a(CaONFJC)MIL389222 035 $a(EXLCZ)992550000000105396 100 $a20081106d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOpioids in cancer pain$b[electronic resource] /$fedited by Mellar Davis ... [et al 205 $a2nd ed. 210 $aOxford ;$aNew York $cOxford University Press$d2009 215 $a1 online resource (500 p.) 300 $aDescription based upon print version of record. 311 $a0-19-923664-X 320 $aIncludes bibliographical references and index. 327 $aContributors; List of abbreviations; 1 Opioid receptors and opioid pharmacodynamics; 2 Opioid pharmacokinetics; 3 Liver disease and exogenous opioid pharmacokinetics; 4 Opioids in renal failure; 5 Codeine; 6 Hydrocodone; 7 Tramadol; 8 Dextropropoxyphene; 9 Morphine; 10 Oxycodone; 11 The lipophilic opioids: fentanyl, alfentanil, sufentanil, and remifentanil; 12 Buprenorphine; 13 Methadone; 14 Hydromorphone; 15 Levorphanol; 16 Diamorphine; 17 Oxymorphone; 18 Choice of opioids and the WHO ladder; 19 Pharmacogenetics and opioids; 20 Opioid rotation; 21 Equi-analgesia. 22 Dosing strategies for acute pain23 Opioid dosing strategies for chronic pain and the management of opioid side effects; 24 Patient-controlled analgesia; 25 Spinal opioids in cancer pain; 26 Opioid poorly responsive pain, physical dependence, tolerance, and opioid-induced hyperalgesia; 27 Opioids in special populations: developing countries; 28 Opioids in special populations: paediatric population; 29 Opioids in the terminal phase; 30 Cancer pain and substance abuse; Index; A; B; C; D; E; F; G; H; I; K; L; M; N; O; P; Q; R; S; T; U; V; W; X. 330 $aOpioids have become invaluable in modern medicine but it is essential that they are prescribed with an understanding of the complex pharmacology behind their effectiveness; without this, they will frequently fail to achieve their enormous potential of pain relief, minimal side effects, and improved function. In addition, opioids come with problems, including side effects such as constipation, respiratory depression, and sedation, as well as the potential for substance abuse.Clinicians handling the complex pain problems of cancer patients must incorporate the insight of basic scientists and pha 606 $aCancer pain$xTreatment 606 $aOpioids 615 0$aCancer pain$xTreatment. 615 0$aOpioids. 676 $a616.994061 701 $aDavis$b Mellar P$01462010 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910779233003321 996 $aOpioids in cancer pain$93670859 997 $aUNINA