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200 10$aEvaluating chemical and other agent exposures for reproductive and developmental toxicity$b[electronic resource] /$fSubcommittee on Reproductive and Developmental Toxicology, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
210   $aWashington, D.C. $cNational Academy Press$dc2001
215   $a1 online resource (262 p.)
225 1 $aCompass series
300   $aDescription based upon print version of record.
311   $a0-309-07316-2 
320   $aIncludes bibliographical references (p. 92-114).
327   $a""EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY""; ""Copyright""; ""Preface""; ""Contents""; ""Abbreviations""; ""EVALUATING CHEMICAL AND OTHER AGENT EXPOSURES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICITY""; ""Summary""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Evaluative Process""; ""Assessing the Available Data""; ""Integration of Toxicity and Exposure Information""; ""Insufficient Data Sets""; ""Application of the Evaluative Process""; ""Sources of Information""; ""Research Recommendations""; ""1 Introduction ""; ""SUBCOMMITTEE'S TASK""
327   $a""ORGANIZATION OF THE REPORT""""2 The Evaluative Process: Part I. Assessing the Available Data ""; ""PRINCIPLES AND OBJECTIVES""; ""Use of Data and Judgment""; ""Weight of Evidence""; ""Threshold Assumption""; ""Narrative Statement""; ""Certainty""; ""Use All Relevant, Acceptable Data""; ""Qualities and Limitations of Reproductive and Developmental Toxicity Studies""; ""Characterizing Data""; ""Expert Review Team""; ""GENERAL DESCRIPTION""; ""DETAILS OF THE EVALUATIVE PROCESS""; ""Exposure Data""; ""General Toxicological and Biological Parameters""; ""Chemistry""; ""Basic Toxicity""
327   $a""Acute Studies""""Repeated-Dose Studies""; ""Genetic Toxicity""; ""Pharmacokinetics""; ""Reproductive and Developmental Toxicity""; ""Human Data""; ""Weighing the Evidence""; ""Case Reports and Clinical Series""; ""Assessing Causality in Human Studies""; ""Experimental Animal Toxicity""; ""Utility and Limitations""; ""Adverse Effect""; ""3 The Evaluative Process: Part II. Integration of Toxicity and Exposure Information ""; ""INTERPRETATION OF TOXICITY DATA""; ""Default Assumptions To Be Considered in Assessing Reproductive and Developmental Toxicity Risk""; ""Absorption""
327   $a""Cross-Species Extrapolation""""Exposure Duration""; ""Windows of Vulnerability""; ""Additivity""; ""QUANTITATIVE EVALUATION""; ""Identification of the NOAEL and LOAEL""; ""Calculation of the Benchmark Dose""; ""Duration Adjustment""; ""Uncertainty Factors""; ""Calculation of the Unlikely Effect Level""; ""Calculation of the Margin of Exposure (MOE)""; ""Assessing a Degree of Concern""; ""Application of Reproductive and Developmental Toxicity Data to Various Exposure Scenarios""; ""Critical Data Needs""; ""SUMMARY""; ""4 Incomplete or Insufficient Data Sets ""
327   $a""PRINCIPLES TO MINIMIZE RISK""""PRACTICAL APPLICATION""; ""REDUCING UNCERTAINTY""; ""5 Recommendations ""; ""GENERAL RECOMMENDATIONS""; ""RESEARCH RECOMMENDATIONS""; ""References""; ""Appendixes""; ""Appendix A Application of the Recommended Evaluative Process to Specific Chemicals ""; ""JP-8 JET FUEL""; ""Exposure Data""; ""General Toxicological and Biological Parameters""; ""Lethality""; ""Acute Studies""; ""Human Studies""; ""Experimental Animal Studies""; ""Repeated-Dose Studies""; ""Human Studies""; ""Experimental Animal Studies""; ""Cancer""; ""Genetic Toxicity""
327   $a""Disposition and Pharmacokinetics""
410  0$aCompass series (Washington, D.C.)
606   $aReproductive toxicology
606   $aDevelopmental toxicology
606   $aToxicity testing
615  0$aReproductive toxicology.
615  0$aDevelopmental toxicology.
615  0$aToxicity testing.
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801  1$bMiAaPQ
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906   $aBOOK
912   $a9910778611203321
996   $aEvaluating chemical and other agent exposures for reproductive and developmental toxicity$93768953
997   $aUNINA