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100   $a20090122d2008      uy             0
101 0 $aeng
135   $aurcn|||||||||
181   $ctxt
182   $cc
183   $acr
200 10$a2-butenal$b[electronic resource] /$ffirst draft prepared by J. Kielborn and I. Mangelsdorf ; and K. Ziegler-Skylakakis
210   $aGeneva $cWorld Health Organization$dc2008
215   $a1 online resource (55 p.)
225 1 $aConcise international chemical assessment document,$x1020-6167 ;$v74
300   $a"IPCS, International Programme on Chemical Safety."
300   $a"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
311   $a9789200530743 
311   $a92-4-153074-X 
320   $aIncludes bibliographical references (p. 32-38).
327   $aCOVER; COPYRIGHT; TABLE OF CONTENTS; FOREWORD; 1. EXECUTIVE SUMMARY; 2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES; 3. ANALYTICAL METHODS; 4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE; 5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, TRANSFORMATION, AND ACCUMULATION; 6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE; 7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS; 8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS; 9. EFFECTS ON HUMANS; 10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD; 11. EFFECTS EVALUATION; 12. PREVIOUS EVALUATIONS BY IOMC BODIES; REFERENCES
327   $aAPPENDICES
330   $a2-Butenal (also known as crotonaldehyde) is an a,-unsaturated aldehyde and consequently a very reactive compound. It is a chemical intermediate used chiefly in the manufacture of sorbates, solvents, and, to a lesser extent, pharmaceutical products and aroma chemicals. This document studies the pharmacokinetics, environmental exposure, chemical toxicology and carcinogenicity of 2-butenal. However, to enable an understanding and evaluation of this aldehyde in the context of environmental health, other aldehydes, such as formaldehyde, acetaldehyde, and acrolein, are mentioned for comparison, where
410  0$aConcise international chemical assessment document ;$v74.
606   $aCrotonaldehyde$xEnvironmental aspects
606   $aCrotonaldehyde$xToxicology
606   $aCrotonaldehyde$xPhysiological effect
615  0$aCrotonaldehyde$xEnvironmental aspects.
615  0$aCrotonaldehyde$xToxicology.
615  0$aCrotonaldehyde$xPhysiological effect.
676   $a363.1791
700   $aKielhorn$b J$01490927
701   $aMangelsdorf$b I$01490929
701   $aZiegler-Skylakakis$b K$01570262
712 02$aWorld Health Organization.
712 02$aUnited Nations Environment Programme.
712 02$aInternational Labour Organisation.
712 02$aInternational Program on Chemical Safety.
712 02$aInter-Organization Programme for the Sound Management of Chemicals.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910778133403321
996   $a2-butenal$93843759
997   $aUNINA