LEADER 04368nam 2200577Ia 450 001 9910778007503321 005 20230124183116.0 010 $a1-60876-410-9 035 $a(CKB)1000000000787689 035 $a(EBL)3018403 035 $a(SSID)ssj0000124414 035 $a(PQKBManifestationID)12018221 035 $a(PQKBTitleCode)TC0000124414 035 $a(PQKBWorkID)10023703 035 $a(PQKB)11060196 035 $a(MiAaPQ)EBC3018403 035 $a(Au-PeEL)EBL3018403 035 $a(CaPaEBR)ebr10660264 035 $a(OCoLC)434995555 035 $a(EXLCZ)991000000000787689 100 $a20071219d2009 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCognitive sciences research progress$b[electronic resource] /$fMiao-Kun Sun, editor 210 $aNew York $cNova Science Publishers$dc2009 215 $a1 online resource (174 p.) 300 $aDescription based upon print version of record. 311 $a1-60456-392-3 320 $aIncludes bibliographical references and index. 327 $a""COGNITIVE SCIENCES RESEARCH PROGRESS""; ""NOTICE TO THE READER""; ""CONTENTS""; ""PREFACE""; ""SUBCELLULAR TRAFFICKING OF BACE1: MOLECULAR MECHANISMS IN THE CONTROL OF I?²-AMYLOID GENERATION""; ""ABSTRACT""; ""INTRODUCTION""; ""PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL FUNCTIONS OF THE I?²-SECRETASE BACE1""; ""THE SUBCELLULAR TRANSPORT OF BACE1""; ""THE ROLE OF THE CYTOPLASMATIC DOMAIN OF BACE1 IN ITS SUBCELLULAR TRAFFICKING""; ""HOW COULD GGA 1 DEPENDENT TRAFFICKING OF BACE1 INFLUENCE AI?² GENERATION ?""; ""CONCLUSIONS""; ""ACKNOWLEDGEMENTS""; ""REFERENCES"" 327 $a""BRAIN VESICULAR MONOAMINE TRANSPORTER AND APOPTOSIS: PERSPECTIVES ON DEVELOPMENT AND NEURODEGENERATION""""ABSTRACT""; ""INTRODUCTION""; ""VMAT2 VERSUS MONOAMINE OXIDASE""; ""DEVELOPMENTAL EXPRESSION OF VMAT2""; ""MICE LACKING VMAT2""; ""VMAT2 AND PROGRAMMED CELL DEATH IN THE CEREBRAL CORTEX""; ""PARKINSON'S DISEASE""; ""SPONSORS""; ""REFERENCES""; ""MILD COGNITIVE IMPAIRMENT IS TOO LATE: THE CASE FOR PRESYMPTOMATIC DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE""; ""ABSTRACT""; ""1. INTRODUCTION""; ""2. THE BRAIN RESERVE HYPOTHESIS"" 327 $a""2.1. Normal Developmental Changes in the Brain during Childhood and Adolescence""""2.2. Education and Cultural Influences""; ""2.3. Genetic and Epigenetic Contributions to Brain Reserve""; ""2.4. Normal Brain Alterations with Aging""; ""2.5. Summary""; ""3. NEURONAL PLASTICITY""; ""3.1. Synaptic Changes with Learning""; ""3.2. Compensations in Brain Injury""; ""3.3. Summary""; ""4. MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD)""; ""4.1. Clinical Approach and Definition of MCI""; ""4.2. Neuropathology of MCI and AD""; ""4.3. Non-AD Neuropathologies"" 327 $a""4.4. The Amyloid Hypothesis and Disease-Modifying Treatment""""4.5. Summary""; ""5. PRESYMPTOMATIC DETECTION OF MCI AND AD""; ""5.1. Evidence for Presymptomatic Neuropathology in AD""; ""5.2. Imaging Biomarkers""; ""5.3. Serum and CSF Biomarkers""; ""5.4. Psychometric Assessments to Predict MCI or AD""; ""5.5. Summary""; ""6. OVERALL SUMMARY AND CONCLUSIONS""; ""6.1. The Argument for Presymptomatic Detection""; ""6.2. Future Directions""; ""ACKNOWLEDGEMENTS""; ""REFERENCES"" 327 $a""SEMANTICALLY MEDIATED INTEGRATION OF COGNITION IN HOMO SAPIENS: EVOLUTION, GRAMMAR, UNCERTAINTY, AND COGNITIVE ACCURACY""""ABSTRACT""; ""INTRODUCTION""; ""BRAIN, BONDING, LANGUAGE, CULTURE, AND EVOLUTION""; ""Bonding and the Limbic System""; ""Differentiation, Language, and Socialization""; ""Cultural Belief Systems""; ""Language, Semantics, grammar, and Cultural Variance""; ""Integration of Semantics and Grammar, Biases, and Cognition""; ""Evolution of Grammar""; ""Evolution of Subjective Cultural Classifications""; ""Ontogeny and Phylogeny of Grammar"" 327 $a""Evolution and Dominance Hierarchies"" 606 $aCognitive science$xResearch 606 $aPhilosophy of mind 615 0$aCognitive science$xResearch. 615 0$aPhilosophy of mind. 676 $a153 701 $aSun$b Miao-Kun$01478434 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910778007503321 996 $aCognitive sciences research progress$93867356 997 $aUNINA