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181   $ctxt
182   $cc
183   $acr
200 10$aFemales are mosaics$b[electronic resource] $eX inactivation and sex differences in disease /$fBarbara R. Migeon
210   $aOxford ;$aNew York $cOxford University Press$d2007
215   $a1 online resource (xi, 271 p., [8] p. of plates )$cill. (some col.)
300   $aFormerly CIP.$5Uk
311   $a0-19-518812-8 
320   $aIncludes bibliographical references (p. 241-257) and index.
330   $a'Females are Mosaics' focuses on the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease.
330   $bWomen can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The father's copy works in some cells, while the mother's copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women.
606   $aX chromosome
606   $aMosaicism
606   $aSex determination, Genetic
606   $aSex-linkage (Genetics)
615  0$aX chromosome.
615  0$aMosaicism.
615  0$aSex determination, Genetic.
615  0$aSex-linkage (Genetics)
676   $a616/.042
700   $aMigeon$b Barbara R$01472956
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906   $aBOOK
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996   $aFemales are mosaics$93686000
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