LEADER 01144nam a2200277|i 4500 001 991003977189707536 005 20030107144504.0 008 020329s2001 at u u freuu 020 $a3700130341 035 $ab11891063-39ule_inst 035 $aEXGIL150667$9ExL 040 $aBiblioteca Interfacoltà$bita 082 0 $a958 100 1 $aTremblay, Xavier$0532599 245 10$aPour une histoire de la Sérinde :$ble manicheisme parmi les peuples et religions d'Asie Centrale d'apres les sources primaires /$cXavier Tremblay 260 0 $aWien :$bOsterreichischen Akademie der Wissenschaften,$c2001 300 $avi, 337 p. :$b1 c. geogr. ripieg. ;$c24 cm. 490 0 $aSitzungsberichte ;$v690 490 0 $aVeroffentlichungen der Kommission fur Iranistik ;$v28 651 4$aAsia centrale$xStoria$ySec. 6.-9. 907 $a.b11891063$b28-04-17$c07-01-03 912 $a991003977189707536 945 $aLE002 St. XXV C 8$g1$i2002000020185$lle002$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i12148520$z07-01-03 996 $aPour une histoire de la Sérinde$9902476 997 $aUNISALENTO 998 $ale002$b01-01-02$cm$da $e-$ffre$gat $h0$i1 LEADER 03393nam 2200601 450 001 9910786043603321 005 20230125183433.0 010 $a1-60807-473-0 035 $a(CKB)2670000000327379 035 $a(EBL)1115666 035 $a(OCoLC)827208675 035 $a(SSID)ssj0000873452 035 $a(PQKBManifestationID)11560564 035 $a(PQKBTitleCode)TC0000873452 035 $a(PQKBWorkID)10878011 035 $a(PQKB)11106807 035 $a(Au-PeEL)EBL1115666 035 $a(CaPaEBR)ebr10818324 035 $a(CaBNVSL)mat09100470 035 $a(IEEE)9100470 035 $a(MiAaPQ)EBC1115666 035 $a(EXLCZ)992670000000327379 100 $a20200730d2012 uy 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEngineering safe and secure software systems /$fC. Warren Axelrod 210 1$aBoston :$cArtech House,$d[2013] 210 2$a[Piscataqay, New Jersey] :$cIEEE Xplore,$d[2012] 215 $a1 online resource (349 p.) 225 1 $aArtech House information security and privacy series 225 0$aArtech House information security and privacy series 300 $aDescription based upon print version of record. 311 $a1-60807-472-2 320 $aIncludes bibliographical references and index. 327 $a1. Introduction -- 2. Engineering Systems -- 3. Engineering Software Systems -- 4. Engineering Secure and Safe Systems, Part 1 -- 5. Secure and Safe Systems, Part 2 -- Secure and Safe Systems, Part 2 -- 6. Software Systems Security and Safety Risk -- 7. Software System Security and Safety Metrics -- 8. Software System Development Processes -- 9. Secure SSDLC Projects in Greater Detail -- 10. Safe SSDLC Projects in Greater Detail -- 11. The Economics of Software Systems' Safety and Security -- Appendices. 330 $a"This first-of-its-kind resource offers a broad and detailed understanding of software systems engineering from both security and safety perspectives. Addressing the overarching issues related to safeguarding public data and intellectual property, the book defines such terms as systems engineering, software engineering, security, and safety as precisely as possible, making clear the many distinctions, commonalities, and interdependencies among various disciplines. You explore the various approaches to risk and the generation and analysis of appropriate metrics. This unique book explains how processes relevant to the creation and operation of software systems should be determined and improved, how projects should be managed, and how products can be assured. You learn the importance of integrating safety and security into the development life cycle. Additionally, this practical volume helps identify what motivators and deterrents can be put in place in order to implement the methods that have been recommended." 410 0$aArtech House information security and privacy series. 606 $aSoftware engineering 606 $aSystems engineering 615 0$aSoftware engineering. 615 0$aSystems engineering. 676 $a620.001/171 700 $aAxelrod$b C. Warren$0491322 801 0$bCaBNVSL 801 1$bCaBNVSL 801 2$bCaBNVSL 906 $aBOOK 912 $a9910786043603321 996 $aEngineering safe and secure software systems$93695335 997 $aUNINA LEADER 03227nam 2200613Ia 450 001 9910779772803321 005 20220912174345.0 010 $a90-04-24861-7 024 7 $a10.1163/9789004248618 035 $a(CKB)2550000001046781 035 $a(EBL)1170040 035 $a(SSID)ssj0000861243 035 $a(PQKBManifestationID)11454391 035 $a(PQKBTitleCode)TC0000861243 035 $a(PQKBWorkID)10914888 035 $a(PQKB)11545890 035 $a(MiAaPQ)EBC1170040 035 $a(OCoLC)847410643 035 $a(nllekb)BRILL9789004248618 035 $a(Au-PeEL)EBL1170040 035 $a(CaPaEBR)ebr10686876 035 $a(CaONFJC)MIL478045 035 $a(OCoLC)841914671 035 $a(PPN)170737497 035 $a(EXLCZ)992550000001046781 100 $a20130207d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBabel's Tower translated$b[electronic resource] $eGenesis 11 and ancient Jewish interpretation /$fby Phillip Michael Sherman 210 $aLeiden ;$aBoston $cBrill$d2013 215 $a1 online resource (377 p.) 225 1 $aBiblical interpretation series ;$vvol. 117 300 $aDescription based upon print version of record. 311 $a90-04-20509-8 320 $aIncludes bibliographical references and index. 327 $aFront Matter -- Interpretation as Translation or Exegesis and Historical Hermeneutics -- Introduction to Part I -- Return to Babel: Reading without the Canon -- Reading Babel Backwards. Canonical Foundations for Exegetical Expansion -- Introduction to Part II -- The Holy Language in the Book of Jubilees: The Tower of Babel and the Eclipse of Sacred Tradition -- Pseudo-Philo?s Biblical Antiquities: Echoes of the Tower -- Josephus and the Influence of Anxiety: Colonizing the Tower and the Politics of Dispersion -- Translated to Heaven: The Tower of Babel and Third (Greek) Baruch -- The Inner Tower: Philo and the Translation of Cultures -- Introduction to Part III -- A Just Translation: Reading the Rabbinic Babel in Genesis Rabbah -- Conclusion -- Bibliography -- Indexes. 330 $aIn Babel's Tower Translated , Phillip Sherman explores the narrative of Genesis 11 and its reception and interpretation in several Second Temple and Early Rabbinic texts (e.g., Jubilees, Philo, Genesis Rabbah). The account of the Tower of Babel (Genesis 11:1-9) is famously ambiguous. The meaning of the narrative and the actions of both the human characters and the Israelite deity defy any easy explanation. This work explores how changing historical and hermeneutical realities altered and shifted the meaning of the text in Jewish antiquity. 410 0$aBiblical interpretation series ;$vvol. 117. 606 $aBabel, Tower of 606 $aRabbinical literature$xHistory and criticism 615 0$aBabel, Tower of. 615 0$aRabbinical literature$xHistory and criticism. 676 $a222/.110609 700 $aSherman$b Phillip Michael$01547758 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910779772803321 996 $aBabel's Tower translated$93804299 997 $aUNINA LEADER 05584nam 2200637 a 450 001 9910781469203321 005 20230914162344.0 010 $a1-283-31219-0 010 $a9786613312198 010 $a90-272-7543-2 035 $a(CKB)2550000000063844 035 $a(EBL)794782 035 $a(OCoLC)768761300 035 $a(SSID)ssj0000992351 035 $a(PQKBManifestationID)11575919 035 $a(PQKBTitleCode)TC0000992351 035 $a(PQKBWorkID)10934627 035 $a(PQKB)10498158 035 $a(MiAaPQ)EBC794782 035 $a(Au-PeEL)EBL794782 035 $a(CaPaEBR)ebr10509632 035 $a(EXLCZ)992550000000063844 100 $a20010514h20022002 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCurrent issues in Romance languages $eselected papers from the 29th Linguistic Symposium on Romance Languages (LSRL), Ann Arbor, 8-11 April 1999 /$fedited by Teresa Satterfield, Christina Tortora, Diana Cresti 210 1$aAmsterdam ;$aPhiladelphia :$cJ. Benjamins Pub.,$d2002. 210 4$a©2002 215 $a1 online resource (vi, 403 pages) 225 1 $aAmsterdam studies in the theory and history of linguistic science. Series IV, Current issues in linguistic theory,$x0304-0763 ;$vv. 220 311 0 $a90-272-3727-1 320 $aIncludes bibliographical references and index. 327 $aCURRENT ISSUES IN ROMANCE LANGUAGES; Editorial page; Title page; Copyright page; Table of contents; PREFACE; ON BECOMING A CLITIC: THE PRENOMINAL POSSESSIVE IN ROMANCE; 0. Introduction; 1. Latin roots; 2. Development from Latin; 2.1 Old French; 2.2 Old Spanish; 2.3 Italian; 3. Syntactic Representation; 4. Conclusion; REFERENCES; PRIMARY STRESS IN SPANISH; 0. Introduction; 1. Data; 2. Test; 3. Analysis; 3.1 Lexical patterns; 3.2 Quantity sensitivity; 3. 3 Falling diphthongs; 3.4 A process in change; 4. Ternary Feet; 5. Conclusion; REFERENCES; SPANISH CLAUSES WITHOUT COMPLEMENTIZER 327 $a1. Introduction 2. Spanish clauses without complementizer; 3. On the presence or absence of the CP projection; 3.1 Topicalization; 3.2 Wh-extraction; 4. On the impossibility of a pre-verbal subject in complementizerless clauses; 5. Conclusion; REFERENCES; ON THE NATURE OF BARE NOUNS IN HAITIAN CREOLE; 1. Introduction; 2. Theoretical Background; 3. The properties of Haitian Creole bare Nouns; 4. HC bare nouns in Chierchia's typology; 5. Evidence for a null determiner in HC; 6. The syntax and semantics of the Haitian Creole null D°; REFERENCES; TOWARDS A SYNTAX OF ADULT ROOT INFINITIVES 327 $a0. Introduction 1. Syntactic properties; 1.1 Adverb placement; 1.2 Left periphery; 1.3 Clausal structure; 2. Some differences; 2.1 Temporal interpretation; 2.2 Topic constructions; 2.3 Subject properties; 2.4 Infinitival raising; 3. Syntactic analysis; 4. Conclusion; REFERENCES; RE-EXAMINING SPANISH 'RESYLLABIFICATION'; 1. Introduction; 2. Data; 3. The Status of Spanish Prefixes; 4. A Theoretical Analysis of Spanish Syllabification; 5. Previous Analyses and Their Shortcomings; 6. Conclusion; REFERENCES; ON PREVERBAL SUBJECTS IN SPANISH; 0. Introduction; 1. Spanish preverbal subjects 327 $a2. Evidence that preverbal subjects are not in topic position 3. Focus/wh-phrases; 4. Evidence that preverbal subjects are not in focus/wh- position; 5. Towards a solution; 6. Conclusions; REFERENCES; THE SEMANTICS OF SPANISH FREE RELATIVES; 1. The morphological encoding of quantificational force; 2. Indefinite FRs; 3. Definite vs. universal FRs; 4. The semantic interpretation of FRs; REFERENCES; SPLIT SUBJECT PRONOUN PARADIGMS: FEATURE GEOMETRY AND UNDER SPECIFICATION; 0. Introduction; 1. Linguistic Atlas Data; 2. How many parameters?; 3. Feature Geometry; 4.Underspecification 327 $a4.1 The tu ~ vous split 5. Splitting the Geometry; 6. Conclusion; REFERENCES; LOCATIVE INVERSION, PP TOPICALIZATION AND THE EPP; 0. Introduction; 1. The transitivity restriction in English; 2. Agr as [+D] head in Spanish; 3. Locative subjects vs. fronted locative PPs in Spanish; 4. PP fronting in Italian; 5. Conclusion; REFERENCES; CONTRAST MAINTENANCE AND INTERVOCALIC STOP LENITION IN SPANISH AND PORTUGUESE: WHEN IS IT ALRIGHT TO LENITE?; 0. Introduction; 1. Lenition Processes; 2. The phonetic implementation of intervocalic stops in Spanish and Portuguese; 3. Experimental design; 4. Results; 5. Conclusions 330 $aThis book presents an enlightening collection of papers contributing to theoretical discussions across many topics within the study of Romance Languages and Linguistics. The work originates from the 29th Linguistic Symposium on Romance Languages held in 1999 at the University of Michigan-Ann Arbor, although only a small subpart of the proceedings papers are included in this volume. The selected papers have been reworked for the current publication. 410 0$aAmsterdam studies in the theory and history of linguistic science.$nSeries IV,$pCurrent issues in linguistic theory ;$v220. 606 $aRomance languages$vCongresses 615 0$aRomance languages 676 $a440 701 $aSatterfield$b Teresa$f1965-$0175877 701 $aTortora$b Christina$0175878 701 $aCresti$b Diana$0175876 712 12$aLinguistic Symposium on Romance Languages 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910781469203321 996 $aCurrent issues in Romance languages$93838760 997 $aUNINA LEADER 02970nam 2200529Ia 450 001 9910777585603321 005 20230421044926.0 035 $a(CKB)1000000000450737 035 $a(EBL)3377716 035 $a(SSID)ssj0000236774 035 $a(PQKBManifestationID)11191370 035 $a(PQKBTitleCode)TC0000236774 035 $a(PQKBWorkID)10172932 035 $a(PQKB)10880324 035 $a(OCoLC)567836181 035 $a(MiAaPQ)EBC3377716 035 $a(EXLCZ)991000000000450737 100 $a20050323d1995 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aResource allocation for family planning in developing countries$b[electronic resource] $ereport of a meeting /$fJohn G. Haaga and Amy O. Tsui, editors ; Committee on Population, Commission on Behavioral and Social Sciences and Education, National Research Council 210 $aWashington, D.C. $cNational Academy Press$d1995 215 $a1 online resource (33 p.) 300 $a"This project was supported by the Office of Population, U.S. Agency for International Development, the Andrew F. Mellon Foundation, and the William and Flora Hewlett Foundation"--T.p. verso. 311 $a0-309-58617-8 320 $aIncludes bibliographical references. 327 $a""Resource Allocation for Family Planning in Developing Countries""; ""Copyright""; ""Contents""; ""Resource Allocation for Family Planning in Developing Countries""; ""CRITERIA FOR THE PUBLIC PROVISION OF SERVICES""; ""THE EFFECTS OF PROGRAM SUBSIDIES ON CONTRACEPTIVE USE AND FERTILITY""; ""THE DISTRIBUTION OF BENEFITS OF SUBSIDIES""; ""ACHIEVING COST REDUCTIONS""; ""ECONOMIES OF SCALE""; ""DIVISION OF LABOR BETWEEN PUBLIC AND PRIVATE SECTORS""; ""MEASURING COSTS AGAINST OUTCOMES""; ""THE POLITICAL SETTING FOR DECISIONS ON FAMILY PLANNING"" 327 $a""IMPLEMENTATION OF REFORMS TO INCREASE FINANCIAL SUSTAINABILITY""""CONCLUSION""; ""REFERENCES""; ""Appendix""; ""THURSDAY, JULY 21""; ""Welcoming Remarks""; ""Potential Effects of Reduced Subsidies""; ""How Would Subsidies Be Reduced?""; ""FRIDAY, JULY 22""; ""What Happens When Foreign Assistance is Reduced?""; ""Wrap-Up Session: Implications for Aid Donors and Governments of Developing Countries"" 606 $aBirth control$zDeveloping countries 606 $aContraceptives$zDeveloping countries 615 0$aBirth control 615 0$aContraceptives 676 $a363.96091724 701 $aHaaga$b John G$01569897 701 $aTsui$b Amy Ong$0638297 712 02$aNational Research Council (U.S.).$bCommittee on Population. 712 02$aNational Research Council (U.S.).$bCommission on Behavioral and Social Sciences and Education. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910777585603321 996 $aResource allocation for family planning in developing countries$93843097 997 $aUNINA LEADER 00877nam0-2200277 --450 001 9910839791803321 005 20240326112955.0 020 $aIT$b79-3848 100 $a20240326d1978----kmuy0itay5050 ba 101 0 $aita 102 $aIT 105 $a 001yy 200 1 $aMorale e filosofia della morale in Erminio Juvalta$fFilippo Picardi 210 $aMilano$cMarzorati$dcopyr. 1978 215 $a220 p.$d24 cm 225 1 $aPubblicazioni dell'Istituto di filosofia, Facoltà di magistero dell'Università di Genova$v24 610 0 $aJuvalta, Erminio$aMorale 676 $a171$v18 700 1$aPicardi,$bFilippo$0217923 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910839791803321 952 $aDAM A70 PICF 01$b2024/4213$fFLFBC 959 $aFLFBC 996 $aMorale e filosofia della morale in Erminio Juvalta$9870189 997 $aUNINA LEADER 01168nam0 22002893i 450 001 VAN00256954 005 20240806101449.163 017 70$2N$a978-3-030-78582-6 100 $a20230412d2021 |0itac50 ba 101 $aeng 102 $aCH 105 $a|||| ||||| 200 1 $aˆAn ‰Introduction to Using Mapping Sentences$fPaul M. W. Hackett, Katelyn Lustig 210 $aCham$cPalgrave Macmillan$d2021 215 $aXIX, 105 p.$d24 cm 620 $aCH$dCham$3VANL001889 700 1$aHackett$bPaul M. W$f1960-$3VANV210467$0941757 701 1$aLustig$bKatelyn$3VANV210468$01347042 712 $aPalgrave Macmillan $3VANV108791$4650 801 $aIT$bSOL$c20240906$gRICA 856 4 $uhttps://doi.org/10.1007/978-3-030-78582-6$zE-book ? Accesso al full-text attraverso riconoscimento IP di Ateneo, proxy e/o Shibboleth 899 $aBIBLIOTECA CENTRO DI SERVIZIO SBA$2VAN15 912 $fN 912 $aVAN00256954 950 $aBIBLIOTECA CENTRO DI SERVIZIO SBA$d15CONS SBA EBOOK 10336 $e15EB 10336 20230412 996 $aIntroduction to Using Mapping Sentences$93082895 997 $aUNICAMPANIA LEADER 06502nam 22005173 450 001 9911020083103321 005 20230812060236.0 010 $a9781394207145 010 $a139420714X 010 $a9781394207091 010 $a1394207093 035 $a(MiAaPQ)EBC30682641 035 $a(Au-PeEL)EBL30682641 035 $a(CKB)27962326400041 035 $a(Exl-AI)30682641 035 $a(Perlego)4208585 035 $a(EXLCZ)9927962326400041 100 $a20230812d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecules Engineered Against Oncogenic Proteins and Cancer $eDiscovery, Design, and Development 205 $a1st ed. 210 1$aNewark :$cJohn Wiley & Sons, Incorporated,$d2023. 210 4$d©2023. 215 $a1 online resource (391 pages) 311 08$aPrint version: Corey, E. J. Molecules Engineered Against Oncogenic Proteins and Cancer Newark : John Wiley & Sons, Incorporated,c2023 9781394207084 327 $aCover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1. Introduction -- 1.1 Types of Protein Kinases -- 1.2 Protein Kinase Domains -- 1.3 ATP-Binding Site -- 1.4 Types of Kinase Inhibitors -- 1.5 Brief History of Small-molecule kinase Inhibitors -- 1.6 Peak 12-Month Sales for Leading Kinase Inhibitors -- 1.7 Approved Kinase Inhibitors -- Chapter 2. BCR-ABL Inhibitors -- 2.1 Imatinib* -- 2.2 Nilotinib* -- 2.3 Dasatinib* -- 2.4 Bosutinib* -- 2.5 Ponatinib* -- 2.6 Olvermbatinib** -- 2.7 Asciminib* -- Chapter 3. BTK Inhibitors -- 3.1 Ibrutinib* -- 3.2 Acalabrutinib* -- 3.3 Zanubrutinib* -- 3.4 Tirabrutinib** -- 3.5 Orelabrutinib** -- Chapter 4. EGFR/HER Family Inhibitors -- 4.1 Gefitinib* -- 4.2 Erlotinib * -- 4.3 Icotinib** -- 4.4 Afatinib* -- 4.5 Dacomitinib* -- 4.6 Osimertinib* -- 4.7 Mobocertinib* -- 4.8 Lapatinib* -- 4.9 Tucatinib* -- 4.10 Neratinib* -- Chapter 5. VEGFR/Multikinase Inhibitors -- 5.1 Sorafenib* -- 5.2 Regorafenib* -- 5.3 Sunitinib* -- 5.4 Pazopanib* -- 5.5 Axitinib* -- 5.6 Nintedanib* -- 5.7 Apatinib** -- 5.8 Lenvatinib* -- 5.9 Tovozanib* -- Chapter 6. CDK4/6 Inhibitors -- 6.1 Palbociclib* -- 6.2 Ribociclib* -- 6.3 Abemaciclib* -- 6.4 Trilaciclib* -- Chapter 7. JAK Inhibitors -- 7.1 Tofacitinib* -- 7.2 Baricitinib* -- 7.3 Peficitinib** -- 7.4 Upadacitinib* -- 7.5 Delgocitinib** -- 7.6 Filgotinib** -- 7.7 Abrocitinib* -- 7.8 Ruxolitinib* -- 7.9 Fedratinib* -- 7.10 Pacritinib* -- 7.11 Ritlecitinib# -- 7.12 Brepocitinib# -- 7.13 Ropsacitinib# -- Chapter 8. Allosteric TYK2 Inhibitors -- 8.1 Deucravacitinib* -- Chapter 9. ALK/multikinase Inhibitors -- 9.1 Crizotinib* -- 9.2 Ceritinib* -- 9.3 Alectinib* -- 9.4 Brigatinib* -- 9.5 Lorlatinib* -- Chapter 10. BRAF/Multikinase Inhibitors -- 10.1 Vemurafenib* -- 10.2 Dabrafenib* -- 10.3 Encorafenib* -- Chapter 11. MEK Inhibitors -- 11.1 Trametinib* -- 11.2 Cobimetinib*. 327 $a11.3 Binimetinib* -- 11.4 Selumetinib* -- Chapter 12. RET/Multikinase Inhibitors -- 12.1 Vandetanib* -- 12.2 Cabozantinib* -- 12.3 Selpercatinib* -- 12.4 Pralsetinib* -- Chapter 13. FGFR Inhibitors -- 13.1 Erdafitinib* -- 13.2 Pemigatinib* -- 13.3 Infigratinib* -- 13.4 Futibatinib* -- Chapter 14. PI3K Inhibitors -- 14.1 Alpelisib* -- 14.2 Idelalisib* -- 14.3 Duvelisib* -- 14.4 Umbralisib* -- 14.5 Copanlisib* -- Chapter 15. TRK/Multikinase Inhibitors -- 15.1 Larotrectinib* -- 15.2 Entrectinib* -- 15.3 Repotrectinib# -- Chapter 16. MET Inhibitors -- 16.1 Capmatinib* -- 16.2 Tepotinib* -- Chapter 17. KIT/PDGFR/Multkinase Inhibitors -- 17.1 Avapritinib* -- 17.2 Ripretinib* -- Chapter 18. FLT3 Inhibitors -- 18.1 Midostaurin* -- 18.2 Gilteritinib* -- Chapter 19. mTOR Inhibitors -- 19.1 Sirolimus* and Analogs -- Chapter 20. Other Kinase Inhibitors -- 20.1 Netarsudil* -- 20.2 Belumosudil* -- 20.3 Fostamatinib* -- 20.4 Pexidartinib* -- Chapter 21. KRAS Inhibitors -- 21.1 Sotorasib* -- 21.2 Adagrasib* -- 21.3 JDQ443# -- Chapter 22. An Overview of the Discovery Process for Medically Useful Inhibitors of Oncogenic Protein Kinases -- 22.1 High-quality Leads -- 22.2 Integrating Substructures from Different High Quality Leads or Established Inhibitors -- 22.3 Variation of Hinge-binding Nucleus -- 22.4 Macrocyclization -- 22.5 Fragment-based Approach -- 22.6 Covalent Inhibitors -- 22.7 Strategic Structural Modification of Prior Drugs -- 22.8 Exploiting Specific Kinase Pocket to Optimize Selectivity -- 22.9 Solvent-exposed Appendages to Enhance Solubility and PK Properties -- Chapter 23. Targeted Molecular Anticancer Therapies - Successes and Challenges -- 23.1 The Beginning -- 23.2 Further Developments -- 23.3 Biomarker-driven Drug Development -- 23.4 Mitigation of Drug Resistance -- 23.5 Miscellaneous Approaches -- 23.6 Discovery Chemistry. 327 $aAppendix 1. First FDA Approvals by Year -- Appendix 2. Kinase/KRAS Inhibitors in Development -- Appendix 3. Visualization of Differentially Expressed Kinases in Cancer -- Appendix 4. M & -- A Transactions Driven by Oncology-focused Kinase and KRAS Inhibitors -- Appendix 5. Alphabetic List of Oncogenic Protein Inhibitors -- EULA. 330 $aThis book provides a comprehensive examination of recent scientific advancements in cancer treatment, focusing on the development of molecular therapies targeting oncogenic proteins. Authored by E. J. Corey and Yong-Jin Wu, it explores the transformation in cancer therapy over the last 30 years through the introduction of nearly 80 FDA-approved synthetic compounds. These compounds specifically target mutated biomolecules responsible for cancer, differing significantly from older cytotoxic agents. The book discusses the role of protein kinases, a class of enzymes integral to cell growth regulation, in cancer proliferation, and highlights the pivotal scientific research enabling these breakthroughs. It is intended for researchers, medical professionals, and students interested in oncology, molecular biology, and drug development.$7Generated by AI. 606 $aProtein kinases$xInhibitors$7Generated by AI 606 $aOncogenes$7Generated by AI 615 0$aProtein kinases$xInhibitors 615 0$aOncogenes 700 $aCorey$b E. J$020674 701 $aWu$b Yong-Jin$01838661 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020083103321 996 $aMolecules Engineered Against Oncogenic Proteins and Cancer$94417695 997 $aUNINA LEADER 03339oam 2200649I 450 001 9910958361903321 005 20251117080332.0 010 $a0-429-92296-5 010 $a0-429-90873-3 010 $a0-429-48396-1 010 $a1-280-12565-9 010 $a9786613529510 010 $a1-84940-959-5 035 $a(CKB)2670000000151292 035 $a(EBL)860789 035 $a(OCoLC)777375524 035 $a(SSID)ssj0000642026 035 $a(PQKBManifestationID)11941667 035 $a(PQKBTitleCode)TC0000642026 035 $a(PQKBWorkID)10646962 035 $a(PQKB)10164153 035 $a(MiAaPQ)EBC860789 035 $a(Au-PeEL)EBL860789 035 $a(CaPaEBR)ebr10535740 035 $a(CaONFJC)MIL352951 035 $a(OCoLC)1029248532 035 $a(FlBoTFG)9780429483967 035 $a(EXLCZ)992670000000151292 100 $a20181122h20182012 uy 0 101 0 $aeng 135 $aur||| ||||| 181 $ctxt 182 $cc 183 $acr 200 10$aThinking of Becoming a Counsellor? /$fby Jonathan Ingrams 205 $aFirst edition. 210 1$aBoca Raton, FL :$cRoutledge,$d[2018]. 210 4$d©2012. 215 $a1 online resource (177 p.) 300 $aDescription based upon print version of record. 311 08$a0-367-10091-6 311 08$a1-78049-016-X 320 $aIncludes bibliographical references and index. 327 $aCOVER; CONTENTS; ABOUT THE AUTHOR; INTRODUCTION; CHAPTER ONE Beginnings; CHAPTER TWO The age of psychoanalysis; CHAPTER THREE The impact of childhood; CHAPTER FOUR The road to self-discovery; CHAPTER FIVE How we construct our world; CHAPTER SIX Inter-relationships; CHAPTER SEVEN The power of conditioning; CHAPTER EIGHT Automatic thoughts and irrational beliefs; CHAPTER NINE The counselling environment today; CONCLUSION; SUGGESTED READING; INDEX 330 3 $aIf you are thinking of becoming a counsellor, you may be wondering if you could put to good use your own life experience by offering support and understanding to those trying to cope with difficulties that you may have encountered and worked through yourself. The ancient Greek aphorism "know thyself" is immensely important in this regard. For unless counsellors are in harmony with themselves they cannot truly relate to the needs of those they seek to help. It is not enough for the counsellor to play the role of the therapist. He or she has to be the therapist - a very different concept. This book explores the journeys of self-discovery that prompted the pioneering practitioners to direct their skills in particular ways and the influence exerted by their backgrounds, ambitions, and personal histories. The overall objective is to help intending therapists to arrive at an understanding of the inner resources they will need to embark on a counselling career, and to help them determine which approach might best accord with their temperament and lifetime's experience. 606 $aPsychology$xVocational guidance 615 0$aPsychology$xVocational guidance. 676 $a158.3 676 $a158.3071 676 $a616.8914 700 $aIngrams$b Jonathan$01879439 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910958361903321 996 $aThinking of Becoming a Counsellor$94492648 997 $aUNINA