LEADER 03907nam 2200625Ia 450 001 9910777466003321 005 20200520144314.0 010 $a1-281-51249-4 010 $a9786611512491 010 $a0-387-77232-4 024 7 $a10.1007/978-0-387-77232-5 035 $a(CKB)1000000000440724 035 $a(EBL)367531 035 $a(OCoLC)272311384 035 $a(SSID)ssj0000252548 035 $a(PQKBManifestationID)11220675 035 $a(PQKBTitleCode)TC0000252548 035 $a(PQKBWorkID)10181054 035 $a(PQKB)10853603 035 $a(DE-He213)978-0-387-77232-5 035 $a(MiAaPQ)EBC367531 035 $a(Au-PeEL)EBL367531 035 $a(CaPaEBR)ebr10239292 035 $a(CaONFJC)MIL151249 035 $a(PPN)12705037X 035 $a(EXLCZ)991000000000440724 100 $a20080121d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStructural and functional organization of the synapse$b[electronic resource] /$fedited by Johannes W. Hell and Michael D. Ehlers 205 $a1st ed. 2008. 210 $aNew York $cSpringer$dc2008 215 $a1 online resource (814 p.) 300 $aDescription based upon print version of record. 311 $a0-387-77231-6 320 $aIncludes bibliographical references and index. 327 $aDiversity in Synapse Structure and Composition -- The Role of Glutamate Transporters in Synaptic Transmission -- Structure and Function of Vertebrate and Invertebrate Active Zones -- Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function -- The Molecular Machinery for Synaptic Vesicle Endocytosis -- Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes -- Adhesion Molecules at the Synapse -- Dendritic Organelles for Postsynaptic Trafficking -- Structure and Mechanism of Action of AMPA and Kainate Receptors -- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity -- Structure and Function of the NMDA Receptor -- Molecular Properties and Cell Biology of the NMDA Receptor -- Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses -- Scaffold Proteins in the Postsynaptic Density -- Ca2+ Signaling in Dendritic Spines -- Postsynaptic Targeting of Protein Kinases and Phosphatases -- Long-Term Potentiation -- Homeostatic Synaptic Plasticity -- Ubiquitin and Protein Degradation in Synapse Function -- Signaling from Synapse to Nucleus -- Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses -- Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology -- Glia as Active Participants in the Development and Function of Synapses -- Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis -- Stroke ? A Synaptic Perspective -- and Pathological Pain. 330 $aSynapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain?s fundamental unit of information storage. 606 $aNeural transmission 606 $aSynapses 615 0$aNeural transmission. 615 0$aSynapses. 676 $a612.81 701 $aEhlers$b Michael D$01560457 701 $aHell$b Johannes W$01560458 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910777466003321 996 $aStructural and functional organization of the synapse$93826424 997 $aUNINA