LEADER 04538oam 2200661Ia 450 001 9910777030103321 005 20231102200141.0 010 $a1-281-23751-5 010 $a9786611237516 010 $a0-470-25981-7 010 $a0-470-25980-9 035 $a(CKB)1000000000411704 035 $a(EBL)333794 035 $a(OCoLC)476138530 035 $a(SSID)ssj0000220590 035 $a(PQKBManifestationID)11910778 035 $a(PQKBTitleCode)TC0000220590 035 $a(PQKBWorkID)10143454 035 $a(PQKB)10291339 035 $a(MiAaPQ)EBC333794 035 $a(Au-PeEL)EBL333794 035 $a(CaPaEBR)ebr10226725 035 $a(CaONFJC)MIL123751 035 $a(PPN)203838874 035 $a(EXLCZ)991000000000411704 100 $a20080128h20082008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPharmaceutical manufacturing handbook $eproduction and processes /$f[edited by] Shayne Cox Gad 210 1$aHoboken, N.J. :$cWiley-Interscience,$d2008. 210 4$dİ2008 215 $a1 online resource (xiii, 1370 pages) $cillustrations 225 1 $aPharmaceutical Development Series 311 0 $a0-470-25958-2 320 $aIncludes bibliographical references and index. 327 $aPHARMACEUTICAL MANUFACTURING HANDBOOK Production and Processes; CONTRIBUTORS; CONTENTS; PREFACE; SECTION 1 MANUFACTURING SPECIALTIES; 1.1 Biotechnology-Derived Drug Product Development; 1.2 Regulatory Considerations in Approval on Follow-On Protein Drug Products; 1.3 Radiopharmaceutical Manufacturing; SECTION 2 ASEPTIC PROCESSING; 2.1 Sterile Product Manufacturing; SECTION 3 FACILITY; 3.1 From Pilot Plant to Manufacturing: Effect of Scale-Up on Operation of Jacketed Reactors; 3.2 Packaging and Labeling; 3.3 Clean-Facility Design, Construction, and Maintenance Issues 327 $aSECTION 4 NORMAL DOSAGE FORMS; 4.1 Solid Dosage Forms; 4.2 Semisolid Dosages: Ointments, Creams, and Gels; 4.3 Liquid Dosage Forms; SECTION 5 NEW DOSAGE FORMS; 5.1 Controlled-Release Dosage Forms; 5.2 Progress in the Design of Biodegradable Polymer-Based Microspheres for Parenteral Controlled Delivery of Therapeutic Peptide/Protein; 5.3 Liposomes and Drug Delivery; 5.4 Biodegradable Nanoparticles; 5.5 Recombinant Saccharomyces cerevisiae as New Drug Delivery System to Gut: In Vitro Validation and Oral Formulation; 5.6 Nasal Delivery of Peptide and Nonpeptide Drugs 327 $a5.7 Nasal Powder Drug Delivery; 5.8 Aerosol Drug Delivery; 5.9 Ocular Drug Delivery; 5.10 Microemulsions as Drug Delivery Systems; 5.11 Transdermal Drug Delivery; 5.12 Vaginal Drug Delivery; SECTION 6 TABLET PRODUCTION; 6.1 Pharmaceutical Preformulation: Physicochemical Properties of Excipients and Powers and Tablet Characterization; 6.2 Role of Preformulation in Development of Solid Dosage Forms; 6.3 Tablet Design; 6.4 Tablet Production Systems; 6.5 Controlled Release of Drugs from Tablet Coatings; 6.6 Tablet Compression; 6.7 Effects of Grinding in Pharmaceutical Tablet Production 327 $a6.8 Oral Extended-Release Formulations; SECTION 7 ROLE OF NANOTECHNOLOGY; 7.1 Cyclodextrin-Based Nanomaterials in Pharmaceutical Field; 7.2 Nanotechnology in Pharmaceutical Manufacturing; 7.3 Pharmaceutical Nanosystems: Manufacture, Characterization, and Safety; 7.4 Oil-in-Water Nanosized Emulsions: Medical Applications; INDEX 330 $aThis handbook features contributions from a team of expert authors representing the many disciplines within science, engineering, and technology that are involved in pharmaceutical manufacturing. They provide the information and tools you need to design, implement, operate, and troubleshoot a pharmaceutical manufacturing system. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. 410 0$aPharmaceutical Development Series;$v5 606 $aPharmaceutical technology$vHandbooks, manuals, etc 606 $aMateria medica$vHandbooks, manuals, etc 615 0$aPharmaceutical technology 615 0$aMateria medica 676 $a615.19 676 $a615/.19 701 $aGad$b Shayne C.$f1948-$096171 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910777030103321 996 $aPharmaceutical manufacturing handbook$93781596 997 $aUNINA