LEADER 04445nam 22005895 450 001 9910770261503321 005 20231216112241.0 010 $a3-031-45278-X 024 7 $a10.1007/978-3-031-45278-9 035 $a(MiAaPQ)EBC31023051 035 $a(Au-PeEL)EBL31023051 035 $a(DE-He213)978-3-031-45278-9 035 $a(MiAaPQ)EBC31093949 035 $a(Au-PeEL)EBL31093949 035 $a(EXLCZ)9929408163200041 100 $a20231216d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAlternate Programmed Cell Death Signaling in Antiviral Host Defense$b[electronic resource] /$fedited by Edward S. Mocarski, Pratyusha Mandal 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (175 pages) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v442 311 08$aPrint version: Mocarski, Edward S. Alternate Programmed Cell Death Signaling in Antiviral Host Defense Cham : Springer International Publishing AG,c2024 9783031452772 327 $aProgrammed Necrosis in Host Defense -- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis -- Pyroptosis in Antiviral Immunity -- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus -- Subversion of Programed Cell Death by Poxviruses -- Cell Killing by Reovirus: Mechanisms and Consequences -- Outcomes of RIP kinase signaling during neuroinvasive viral infection. 330 $aThis volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v442 606 $aImmunology 606 $aMedical microbiology 606 $aVirology 606 $aImmunology 606 $aMedical Microbiology 606 $aVirology 615 0$aImmunology. 615 0$aMedical microbiology. 615 0$aVirology. 615 14$aImmunology. 615 24$aMedical Microbiology. 615 24$aVirology. 676 $a616.9101 700 $aMocarski$b Edward S$01460543 701 $aMandal$b Pratyusha$01460544 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910770261503321 996 $aAlternate Programmed Cell Death Signaling in Antiviral Host Defense$93660345 997 $aUNINA