LEADER 03082nam 22006135 450 001 9910768445003321 005 20251113201224.0 010 $a981-16-5419-0 024 7 $a10.1007/978-981-16-5419-0 035 $a(MiAaPQ)EBC6964818 035 $a(Au-PeEL)EBL6964818 035 $a(CKB)21707956600041 035 $a(PPN)262170396 035 $a(OCoLC)1313480026 035 $a(DE-He213)978-981-16-5419-0 035 $a(EXLCZ)9921707956600041 100 $a20220428d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGene Delivery /$fedited by Huayu Tian, Xuesi Chen 205 $a1st ed. 2022. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022. 215 $a1 online resource (567 pages) 225 1 $aBiomaterial Engineering,$x2523-8817 311 08$aPrint version: Tian, Huayu Gene Delivery Singapore : Springer,c2022 9789811654183 320 $aIncludes bibliographical references and index. 327 $aOverview on gene therapy -- Cationic liposome -- Functionalized peptide dendrimers -- Bioresponsive poly(amido amine)s -- Cationic polyphosphoesters -- Polysaccharide-based gene carriers -- Polypeptide-based gene carriers -- Fluorinated gene carriers -- Target gene delivery systems -- Cationic helical polypeptides -- Cyclic cationic polymers -- Cationic bolaamphiphile -- Chitosan-functionalized gene carriers -- Charge-reversal gene carriers -- Multifunctional envelope-type nanodevice -- Drug and gene co-delivery systems -- Oral delivery of gene therapy -- Gene therapy for brain diseases. 330 $aGene delivery is a promising strategy for the specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this volume, the recent developments of nanoparticles for clinical gene therapy will be identified and summarized. 410 0$aBiomaterial Engineering,$x2523-8817 606 $aBiomedical engineering 606 $aBiomaterials 606 $aMedical genetics 606 $aBiomedical Engineering and Bioengineering 606 $aBiomaterials 606 $aMedical Genetics 615 0$aBiomedical engineering. 615 0$aBiomaterials. 615 0$aMedical genetics. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aBiomaterials. 615 24$aMedical Genetics. 676 $a170 702 $aTian$b Huayu 702 $aChen$b Xuesi 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910768445003321 996 $aGene Delivery$92852955 997 $aUNINA