LEADER 05059nam 22006255 450 001 9910767564803321 005 20231124005145.0 010 $a3-031-37936-5 024 7 $a10.1007/978-3-031-37936-9 035 $a(MiAaPQ)EBC30967773 035 $a(Au-PeEL)EBL30967773 035 $a(DE-He213)978-3-031-37936-9 035 $a(CKB)29030218800041 035 $a(EXLCZ)9929030218800041 100 $a20231123d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSyncytia: Origin, Structure, and Functions /$fedited by Malgorzata Kloc, Ahmed Uosef 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (480 pages) 225 1 $aResults and Problems in Cell Differentiation,$x1861-0412 ;$v71 311 08$aPrint version: Kloc, Malgorzata Syncytia: Origin, Structure, and Functions Cham : Springer International Publishing AG,c2023 327 $aPart I. Germline Syncytia, Evolution, Function, and Structure -- Chapter 1. The Ancient Origin and Function of Germline Cysts -- Chapter 2. Female Germline Cysts in Animals: Evolution and Function -- Chapter 3. Germline and Somatic Cell Syncytia in Insects -- Part II. Syncytia in Embryogenesis and Development -- Chapter 4. Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development -- Chapter 5. Cell-Mediated Branch Fusion in the Drosophila Trachea -- Chapter 6. Trophoblast Syncytialization: A Metabolic Crossroads -- Chapter 7. Early Syncytialization of the Ovine Placenta Revisited -- Chapter 8. Syncytia in Utricularia: Origin and Structure -- Part III. Fungal and Somatic Cell Syncytia and Genomic View of Extremophiles as the Ancestral Precursors of Eukaryotic Syncytia -- Chapter 9. Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis -- Chapter 10. Ancestors in The Extreme: A Genomics View of Microbial Diversity in Hypersaline Aquatic Environments -- Chapter 11. Somatic Cell Fusion in Host Defense and Adaptation -- Chapter 12. Osteoclasts at Bone Remodeling: Order from Order -- Chapter 13. Muscle Progenitor Cell Fusion in the Maintenance of Skeletal Muscle -- Part IV. Virus- and Parasite- Induced Syncytia -- Chapter 14. Virus-Induced Cell Fusion and Syncytia Formation -- Chapter 15. HIV-1 Induced Cell-to-Cell Fusion or Syncytium Formation -- Chapter 16. Relevance of the Entry by Fusion at the Cytoplasmic Membrane vs. Fusion After Endocytosis in the HIV and SARS-Cov-2 Infections -- Chapter 17. Mathematical Modeling of Virus-Mediated Syncytia Formation: Past Successes and Future Directions -- Chapter 18. Syncytium Induced by Plant-Parasitic Nematodes -- Part V. Cell Fusion and Syncytia in Cancer -- Chapter 19. Mechanisms of Cell Fusion in Cancer -- Chapter 20. Cell Fusion and Syncytia Formation in Cancer -- Chapter 21. The Hallmarks of Circulating Hybrid Cells. 330 $aThis book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis and organogenesis. It also reviews pathogen-induced syncytia and the role of syncytial cells in cancer development. The book covers the following topics: germline syncytia, evolution, function and structure; syncytia in embryogenesis and development; the role of somatic cell fusion in fungi, specialized somatic tissues, host defense and adaptation; syncytia induced by viruses and parasites; syncytia and circulating hybrid cells in cancer and other pathological conditions; It also discusses how the genomic adaptations of microorganisms to extreme habitats can prompt the evolution of mononuclear and multinucleate/syncytial cells. The book offers a fresh outlook on syncytia's role in various processes: embryogenesis, organogenesis, adaptation, host defense, and development of specialized tissues. It highlights the importance of syncytia under physiological and pathological conditions. 410 0$aResults and Problems in Cell Differentiation,$x1861-0412 ;$v71 606 $aCell differentiation 606 $aDevelopmental biology 606 $aStem cells 606 $aCytology 606 $aCell Differentiation 606 $aDevelopmental Biology and Stem Cells 606 $aStem Cell Biology 606 $aCell Biology 615 0$aCell differentiation. 615 0$aDevelopmental biology. 615 0$aStem cells. 615 0$aCytology. 615 14$aCell Differentiation. 615 24$aDevelopmental Biology and Stem Cells. 615 24$aStem Cell Biology. 615 24$aCell Biology. 676 $a571.845 700 $aKloc$b Malgorzata$01453555 701 $aUosef$b Ahmed$01453556 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910767564803321 996 $aSyncytia: Origin, Structure, and Functions$93656201 997 $aUNINA