LEADER 04530nam 22005655 450 001 9910767551303321 005 20230705095836.0 010 $a3-319-89521-4 024 7 $a10.1007/978-3-319-89521-5 035 $a(CKB)4100000004243919 035 $a(DE-He213)978-3-319-89521-5 035 $a(MiAaPQ)EBC6284731 035 $a(PPN)227402626 035 $a(EXLCZ)994100000004243919 100 $a20180503d2018 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFree-Radical Synthesis and Functionalization of Heterocycles /$fedited by Yannick Landais 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (VII, 352 p. 454 illus., 18 illus. in color.) 225 1 $aTopics in Heterocyclic Chemistry,$x1861-9282 ;$v54 311 $a3-319-89520-6 327 $aPhotocatalyzed Formation of Heterocycles -- C?H activation via radical processes using photo-excited ketones -- Free Radicals in Heterocycle Functionalization -- Heteroatom-Centred Radicals for the Synthesis of Heterocyclic Compounds -- Metal-Mediated Oxidative Radical Processes for the Synthesis of Heterocycles -- Reductive Electron Transfer in the Synthesis of Heterocycles -- Synthesis of Nitrogen-Containing Heterocycles via Imidoyl or Iminyl Radical Intermediates -- Radical cascades in the total synthesis of complex naturally occurring heterocycles. 330 $aThis volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups. Photochemical activation, for a long time the preferred mode of activation in radical chemistry has also seen an unexpected revival with the advent of visible light metal- and organocatalyzed photoredox processes. A survey of these emerging areas is provided along with the concepts at the origin of these developments. The venerable Minisci reaction allows for direct access to functionalized heterocycles. This process has lately seen an interesting renaissance and is discussed in this volume. Addition of heteroatom-centered radicals onto unsaturated systems constitutes another powerful method to construct heterocycles. Examples of such a strategy are proposed along with the formation of various heterocycles relying on homolytic substitution at sulfur, phosphorus and selenium. Additionally free-radical functionalization of reactive functional groups including isonitriles, isothiocyanates and related unsaturated systems which offer a straightforward route towards useful aromatic and non-aromatic heterocycles are discussed. Finally, as metals are able to trigger single electron transfer both in reductive and oxidative modes this provides another possibility for the synthesis of heterocycles. Significant research efforts have focussed on the use of samarium, copper and other metals to access a broad variety of heterocycles in a single pot process, starting from readily available raw material. Examples and mechanistic insights are discussed by experts in this area. 410 0$aTopics in Heterocyclic Chemistry,$x1861-9282 ;$v54 606 $aOrganic chemistry 606 $aCatalysis 606 $aGreen chemistry 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 606 $aCatalysis$3https://scigraph.springernature.com/ontologies/product-market-codes/C29000 606 $aGreen Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C35000 615 0$aOrganic chemistry. 615 0$aCatalysis. 615 0$aGreen chemistry. 615 14$aOrganic Chemistry. 615 24$aCatalysis. 615 24$aGreen Chemistry. 676 $a547.59 702 $aLandais$b Yannick$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910767551303321 996 $aFree-Radical Synthesis and Functionalization of Heterocycles$91566587 997 $aUNINA