LEADER 05809nam 22006615 450 001 9910767503903321 005 20231201093116.0 010 $a3-031-43883-3 024 7 $a10.1007/978-3-031-43883-7 035 $a(MiAaPQ)EBC30980141 035 $a(Au-PeEL)EBL30980141 035 $a(DE-He213)978-3-031-43883-7 035 $a(CKB)29128102400041 035 $a(EXLCZ)9929128102400041 100 $a20231201d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aImplication of Oxysterols and Phytosterols in Aging and Human Diseases /$fedited by Gérard Lizard 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (455 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1440 311 08$aPrint version: Lizard, Gérard Implication of Oxysterols and Phytosterols in Aging and Human Diseases Cham : Springer International Publishing AG,c2024 9783031438820 327 $aPart I. Chemical Characteristics -- Chapter 1. The Structure of Oxysterols Determines their Behavior at Phase Boundaries ? Implications for Model Membranes and Structure-Activity Relationships -- Chapter 2. Association of ABCG5 and ABCG8 Transporters with Sitosterolemia -- Part II. Bio- and Chemical- Synthesis, and Analytical Methods -- Chapter 3. Chemical and Biochemical Features of Spinasterol and Schottenol -- Chapter 4. LC-MS Approaches for Oxysterols in Various Biosamples -- Chapter 5. Mass Spectrometry Imaging of Cholesterol and Oxysterols -- Part III. Implication in Aging and Human Diseases -- Chapter 6. Oxysterols in Central and Peripheral Synaptic Communication -- Chapter 7. Oxysterols in Infectious Diseases -- Chapter 8. The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases -- Chapter 9. Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects -- Chapter 10. Enzymatically Formed Oxysterols and Cell Death -- Chapter 11. Oxysterols in Vascular Cells and Role in Atherosclerosis -- Chapter 12. Implication of Oxysterols and Phytosterols in Aging and Human Diseases -- Chapter 13. Sterols in Inflammatory Diseases: Implications and Clinical Utility -- Chapter 14. Role of Oxysterols in Ocular Degeneration Mechanisms and Involvement of P2X7 Receptor -- Chapter 15. 24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder and Bipolar Disorder -- Part IV. Biomarkers Therapeutic and Industrial Applications -- Chapter 16. Oxysterols as Biomarkers of Aging and Disease -- Chapter 17. The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease -- Chapter 18. Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives -- Part V. Pharmacological Applications -- Chapter 19. Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancer -- Part VI. Industrial Aspects -- Chapter 20. Current and New Insights on Delivery Systems for Plant Sterols in Food -- Chapter 21. In vitro Evaluation of the Effects of 7-Ketocholesterol and 7?-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy -- Chapter 22. Phytosterols: Potential Therapeutic Effects and Challenges in Food Industry. 330 $aThis book provides basic knowledge of the biology, chemistry, and function of oxysterols and its derivatives as well as of phytosterols in numerous human diseases. The book is divided into six sections and begins with an introduction to the biological and chemical properties of oxysterols and its derivatives as well as phytosterols, their synthesis, and the methods currently used for their detection in various biospecimens. The following section discusses in detail the various effects of oxysterols on numerous human diseases, including infectious diseases, inflammatory and autoimmune diseases, atherosclerosis, and cancer, as well as neurological and neuropsychiatric disorders. Importantly, the potential of oxysterols as biomarkers for some of these diseases is also highlighted. The book concludes with an outlook on the pharmacological and nutritional effects of oxysterols and phytosterols and their potential use by the food, and pharmaceutical industries. Aiming to provide an in-depth overview of the biological and the chemical properties of oxysterols and phytosterols and their implications for human health, this book will be of interest to basic and clinical scientists, as well as to anyone working in the food or pharmaceutical industry who is exploring the potential of oxysterols and phytosterols. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1440 606 $aCytology 606 $aLipids 606 $aClinical biochemistry 606 $aCancer 606 $aInflammation 606 $aCell Biology 606 $aLipidology 606 $aMedical Biochemistry 606 $aCancer Biology 606 $aInflammation 615 0$aCytology. 615 0$aLipids. 615 0$aClinical biochemistry. 615 0$aCancer. 615 0$aInflammation. 615 14$aCell Biology. 615 24$aLipidology. 615 24$aMedical Biochemistry. 615 24$aCancer Biology. 615 24$aInflammation. 676 $a571.6 700 $aLizard$b Gérard$01453310 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910767503903321 996 $aImplication of Oxysterols and Phytosterols in Aging and Human Diseases$93655902 997 $aUNINA