LEADER 02427nam 2200361 450 001 9910765833703321 005 20230224103925.0 010 $a3-03897-297-5 035 $a(CKB)5400000000000134 035 $a(NjHacI)995400000000000134 035 $a(EXLCZ)995400000000000134 100 $a20230224d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular pathways of estrogen receptor action /$fedited by Farzad Pakdel 210 1$aBasel, Switzerland :$cMDPI,$d[2018] 210 4$dİ2018 215 $a1 online resource (304 pages) $cillustrations 320 $aIncludes bibliographical references. 330 $aEstrogen receptors (ERs) are typical members of the superfamily of nuclear receptors that mainly function as ligand-inducible transcription factors that bind chromatin, as homodimers, at specific response elements. A tight reciprocal coupling between rapid 'non-genomic' and 'genomic' ER actions may also occur in many physiological processes. ERs have long been evaluated for their roles in controlling the expression of genes involved in vital cellular processes such as proliferation, apoptosis, and differentiation. Therefore, given the various and pleiotropic functions of ERs, the dysregulation of their pathways contributes to several diseases such as the hormone-dependent breast; endometrial and ovarian cancers; and neurodegenerative diseases, cardiovascular diseases, and osteoporosis. In this printed edition of the Special Issue, "Molecular Pathways of Estrogen Receptor Action", promising results on understanding the mechanisms underlying ER-mediated effects in various pathophysiological processes are represented, covering different roles of ER pathways in the tumorigenesis, the resistance to endocrine therapy, the dynamics of 3D genome organization, and cross-talk with other signaling pathways. This Special Issue also provides insight into the emerging roles of estrogen-signaling pathways in lung cancer, the tumor microenvironment, and the immune system. 606 $aEstrogen$xReceptors 615 0$aEstrogen$xReceptors. 676 $a573.44 702 $aPakdel$b Farzad 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910765833703321 996 $aMolecular Pathways of Estrogen Receptor Action$92932984 997 $aUNINA