LEADER 00939nam0-22003251i-450- 001 990003772280403321 005 20051109125054.0 010 $a0-669-00973-3 035 $a000377228 035 $aFED01000377228 035 $a(Aleph)000377228FED01 035 $a000377228 100 $a20030910d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aWomen in Management$fLaurie Larwood, Marion M. Wood. 210 $aLexington$cD.C. Heath and Company$dİ1977 215 $axiv, 199 p.$ctav.$d23 cm 610 0 $aDonne imprenditrici$aStati Uniti 676 $a305.4365840973$v21$zita 676 $a331.48165840973$v21$zita 700 1$aLarwood,$bLaurie$0143339 702 1$aWood,$bMarion M. 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003772280403321 952 $a305.4365840973 L 1$b2203$fBFS 959 $aBFS 996 $aWomen in Management$9510767 997 $aUNINA LEADER 04696nam 22003613a 450 001 9910765829103321 005 20250203235426.0 010 $a9783038976639 010 $a3038976636 024 8 $a10.3390/books978-3-03897-663-9 035 $a(CKB)5400000000000093 035 $a(ScCtBLL)df0697cc-87bb-4c72-a2bf-c8e4017adbe3 035 $a(OCoLC)1105784343 035 $a(EXLCZ)995400000000000093 100 $a20250203i20192019 uu 101 0 $aeng 135 $auru|||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAMP-Activated Protein Kinase Signalling$fDietbert Neumann, Benoit Viollet 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 online resource (1 p.) 330 $aStarting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included. 610 00$aexercise; glucose uptake; AMP-activated protein kinase; TBC1D4; AS160; AMP-activated protein kinase; developmental origins of health and disease (DOHaD); hypertension; kidney disease; nutrient-sensing signals; oxidative stress; renin-angiotensin system; AMPK; autophagy; co-expression; microarrays; 3T3-L1; adipocyte; differentiation; AMPK; tight junctions; epithelial cells; ZO-1; par complex; MDCK; nectin-afadin; adherent junctions; TAK1; AMPK; phosphorylation; AMPK kinase; endothelial nitric-oxide synthase; vasodilation; phenylephrine; vasoconstriction; endothelial cells; ionomycin; AMPK; liver; lipid metabolism; fatty acid oxidation; indirect calorimetry; atrophy; regrowth; sirtuin 1 (SIRT1); peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?); heat shock protein; fiber-type; AMPK; monocytes; macrophages; differentiation; autophagy; AML; MDS; CML; CMML; pregnancy; catechol-O-methyltransferase; 2-methoxyestradiol; preeclampsia; gestational diabetes mellitus; AMPK; IL-1?; NLRP3; nutrition; dietary fatty acids; metabolic-inflammation; nutrigenomics; AMPK; LKB1; autophagy; proteasome; hypertrophy; atrophy; skeletal muscle; AICAR; mTOR; protein synthesis; AMPK; epigenetics; chromatin remodeling; histone modification; DNA methylation; medulloblastoma; sonic hedgehog; AMPK; AMP-activated protein kinase (AMPK); spermatozoa; motility; mitochondria; membranes; signaling; stress; assisted reproduction techniques; AMP-activated protein kinase; epigenetics; protein acetylation; KATs; HDACs; acetyl-CoA; NAD+; AMP-activated protein kinase; glycogen; exercise; metabolism; cellular energy sensing; energy utilization; liver; skeletal muscle; metabolic disease; glycogen storage disease; resveratrol; AMPK; hepatocyte; liver; steatosis; transporter; carrier; pump; membrane; energy deficiency; AMPK; infection; mycobacteria; host defense; energy metabolism; AMPK; activation loop; AID; ?-linker; ?-linker; CBS; LKB1; CaMKK2; ?RIM; hypothalamus; adenosine monophosphate-activated protein kinase; adipose tissue; food intake; adaptive thermogenesis; beiging; AMPK; HDAC4/5; p70S6K; MyHC I(?)$amotor endplate remodeling; soleus muscle; mechanical unloading; hindlimb suspension; AMPK; synaptic activation; PKA; CREB; soluble Adenylyl cyclase; Immediate early genes; transcription; AMPK; autophagy; metabolism; mTOR; ULK; AMP-activated protein kinase; protein kinase B; Akt; insulin signalling; A769662; endothelial function; n/a 700 $aNeumann$b Dietbert$01277609 702 $aViollet$b Benoit 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910765829103321 996 $aAMP-Activated Protein Kinase Signalling$93011715 997 $aUNINA