LEADER 02383nam 2200385 450 001 9910765538203321 005 20240215175051.0 010 $a1-83768-400-6 035 $a(CKB)5580000000706380 035 $a(NjHacI)995580000000706380 035 $a(EXLCZ)995580000000706380 100 $a20240215d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThalassemia Syndromes - New Insights and Transfusion Modalities /$fMarwa Zakaria (and three others) 210 1$aLondon :$cIntechOpen,$d2023. 215 $a1 online resource (242 pages) 311 $a1-83768-399-9 327 $a1. Overview of Beta-Thalassemia -- 2. Effects of Beta-Thalassemia on COVID-19 Outcomes -- 3. Newborn Screening and Thalassaemia Syndrome -- 4. The Key Genetic Determinants Behind the Phenotypic Heterogeneity of HbE/?-thalassemia Patients and the Probable Management Strategy -- 5. Interaction of Thalassemia and Hb Variants in Southeast Asia: Genotype-Phenotype Relationship -- 6. The Thalassemia Syndromes: New Insights -- 7. Optimizing Blood Transfusion Service Delivery across the West African Sub-Region -- 8. Clinical Effects and Possible Mechanisms of Transfusion-Related Immunomodulation -- 9. Personnel for Blood Transfusion Services in Nigeria: A Multicenter Cooperative Study. 330 $aThe thalassemia syndromes are a diverse group of hereditary anemias caused by decreased or absent production of one type of globin chain. Genetic counseling, prenatal diagnosis, and newborn screening are all issues of importance in these inherited disorders. This book provides a comprehensive overview of thalassemia, including information on its mechanisms and treatment modalities. Chapters elucidate the mechanism of disordered synthesis of hemoglobin in thalassemia and present recent studies of the genetic mechanisms that underlie this abnormal biosynthetic process. 606 $aThalassemia$xLaw and legislation 606 $aThalassemia 615 0$aThalassemia$xLaw and legislation. 615 0$aThalassemia. 676 $a616.152 702 $aMarwa Zakaria 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910765538203321 996 $aThalassemia Syndromes - New Insights and Transfusion Modalities$93654092 997 $aUNINA