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035   $a(DE-He213)978-981-15-8473-2
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100   $a20231120d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aRole of Signaling Pathways in Brain Tumorigenesis /$fby Mehdi Hayat Shahi
205   $a1st ed. 2023.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023.
215   $a1 online resource (215 pages)
311 08$aPrint version: Shahi, Mehdi Hayat Role of Signaling Pathways in Brain Tumorigenesis Singapore : Springer,c2024 
327   $aIntroduction of Cell signalling Pathways and Brain Tumours -- Wnt cell signalling pathway and brain tumours development -- Notch cell signalling pathway and Brain Tumours -- Shh cell signalling pathway and paediatric brain tumour ?Medulloblastoma? -- Role of Shh cell signalling pathway in ?glioma? -- Role of stem cell marker NANOG in brain tumours development -- Stem cell factor Sox2 and Brain Tumours Development -- Role of Neurotrophins in brain tumor development -- Role of NFk? in brain tumour development -- Role of Myc in brain tumours development -- Role of P53 in Medulloblastoma Development -- Role of Gene TP53 in glioblastoma development -- Role of HIF-1 in Brain Tumour Development -- EGFR and its role in glioma development -- Role of EFGR in medulloblastoma development -- Role of OCT4 in glioblastoma development -- Role of OCT4 in paediatric brain tumour ?medulloblastoma? development -- Role of Mitogen activated protein (MAP) Kinase in paediatric brain tumour ?medulloblastoma?.
330   $aThis book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours. .
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aZoology
606   $aMedical genetics
606   $aCytokines
606   $aBrain Neoplasms
606   $aGenetics, Medical
606   $aCytokines
606   $aBiomedical Research
606   $aSignal Transduction
606   $aCarcinogenesis
606   $aBiomedical Research
606   $aZoology
606   $aMedical Genetics
606   $aCytokines and Growth Factors
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aZoology.
615  0$aMedical genetics.
615  0$aCytokines.
615  2$aBrain Neoplasms.
615  2$aGenetics, Medical.
615  2$aCytokines.
615  2$aBiomedical Research.
615  2$aSignal Transduction.
615  2$aCarcinogenesis
615 14$aBiomedical Research.
615 24$aZoology.
615 24$aMedical Genetics.
615 24$aCytokines and Growth Factors.
676   $a610.72
700   $aShahi$b Mehdi Hayat$01448973
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910765489503321
996   $aRole of Signaling Pathways in Brain Tumorigenesis$93644957
997   $aUNINA