LEADER 04548nam 22006255 450 001 9910754099103321 005 20240124224227.0 010 $a9789819946570$b(electronic bk.) 010 $z9789819946563 024 7 $a10.1007/978-981-99-4657-0 035 $a(MiAaPQ)EBC30799978 035 $a(Au-PeEL)EBL30799978 035 $a(DE-He213)978-981-99-4657-0 035 $a(PPN)272919683 035 $a(EXLCZ)9928528638600041 100 $a20231019d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCytokine and Chemokine Networks in Cancer$b[electronic resource] /$fedited by Manzoor Ahmad Mir 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (449 pages) 311 08$aPrint version: Mir, Manzoor Ahmad Cytokine and Chemokine Networks in Cancer Singapore : Springer,c2023 9789819946563 320 $aIncludes bibliographical references. 327 $aChapter 1_Introduction to Cancer -- Chapter 2_Expression pattern of Chemokines in Cancer -- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer -- Chapter 4_Cytokine and chemokines networks in cancer stemness -- Chapter 5_Cytokine and chemokines networks in angiogeneis -- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition -- Chapter 7_Role of Chemokines in establishment of Metastatic Niche -- Chapter 8_CXCL12-CXCR4 axis in Metastasis -- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment -- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation -- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases -- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance -- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer -- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer -- Chapter 15_Chemokines in cancer therapy. 330 $aCytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine. 606 $aCancer 606 $aTumors$xImmunological aspects 606 $aTherapeutics 606 $aNeoplasms 606 $aChemokines 606 $aCytokines 606 $aCancers 606 $aTumour Immunology 606 $aTherapeutics 615 0$aCancer. 615 0$aTumors$xImmunological aspects. 615 0$aTherapeutics. 615 2$aNeoplasms. 615 2$aChemokines. 615 2$aCytokines. 615 14$aCancers. 615 24$aTumour Immunology. 615 24$aTherapeutics. 676 $a616.994061 702 $aMir$b Manzoor Ahmad 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910754099103321 996 $aCytokine and Chemokine Networks in Cancer$93585039 997 $aUNINA