LEADER 04668nam 22007695 450 001 9910754089903321 005 20260209150440.0 010 $a9783031387319$b(electronic bk.) 010 $z9783031387302 024 7 $a10.1007/978-3-031-38731-9 035 $a(MiAaPQ)EBC30795564 035 $a(Au-PeEL)EBL30795564 035 $a(DE-He213)978-3-031-38731-9 035 $a(PPN)272919799 035 $a(CKB)28527607200041 035 $a(EXLCZ)9928527607200041 100 $a20231018d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCPP, Cell-Penetrating Peptides /$fby Ülo Langel 205 $a2nd ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (564 pages) 311 08$aPrint version: Langel, Ülo CPP, Cell-Penetrating Peptides Cham : Springer International Publishing AG,c2023 9783031387302 327 $a1. Introduction -- 2. Classes and applications of CPP -- 3. CPP selection, prediction and in silico analysis -- 4. Labeling of CPPs -- 5. Methods for CPP functionalization with oligonucleotides -- 6. Additional (gene therapeutic) platforms -- 7. Protein delivery and mimicry -- 8. General targeting strategies -- 9. Targeting specific barriers -- 10. Methods for molecular imaging, detection and visualization of CPPs -- 11. Methods for structural studies of CPPs -- 12. Kinetics -- 13. Toxicity and immune response -- 14. Cell-translocation mechanisms of CPPs -- 15. Clinical trials and commercialization using CPPs -- 16. Therapeutic potential of CPPs -- 17. CPP functionalized nanoparticles -- 18. Concluding remarks. 330 $aIn this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field. 606 $aDrug delivery systems 606 $aProteins 606 $aPharmacology 606 $aProteins 606 $aPharmaceutical chemistry 606 $aBiomaterials 606 $aDrug Delivery 606 $aProteins 606 $aPharmacology 606 $aProtein Biochemistry 606 $aMedicinal Chemistry 606 $aBiomaterials-Proteins 606 $aProteòmica$2thub 606 $aMedicaments peptídics$2thub 608 $aLlibres electrònics$2thub 615 0$aDrug delivery systems. 615 0$aProteins. 615 0$aPharmacology. 615 0$aProteins. 615 0$aPharmaceutical chemistry. 615 0$aBiomaterials. 615 14$aDrug Delivery. 615 24$aProteins. 615 24$aPharmacology. 615 24$aProtein Biochemistry. 615 24$aMedicinal Chemistry. 615 24$aBiomaterials-Proteins. 615 7$aProteòmica 615 7$aMedicaments peptídics 676 $a572.65 676 $a572.65 700 $aLangel$b U?lo$00 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910754089903321 996 $aCPP, Cell-Penetrating Peptides$92140606 997 $aUNINA