LEADER 05229nam 22007695 450 001 9910751389003321 005 20240126232959.0 010 $a3-031-29223-5 024 7 $a10.1007/978-3-031-29223-1 035 $a(MiAaPQ)EBC30787864 035 $a(Au-PeEL)EBL30787864 035 $a(DE-He213)978-3-031-29223-1 035 $a(PPN)272917079 035 $a(CKB)28505213100041 035 $a(EXLCZ)9928505213100041 100 $a20231014d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aImmunotherapy for Head and Neck Cancer /$fedited by Anthony T. C. Chan, Brigette B.Y. Ma 205 $a1st ed. 2023. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2023. 215 $a1 online resource (151 pages) 225 1 $aCancer Immunotherapy,$x2662-8392 ;$v1 311 08$aPrint version: Chan, Anthony T. C. Immunotherapy for Head and Neck Cancer Cham : Springer,c2023 9783031292224 327 $aImmunological Landscape of Head and Neck Cancer: Mechanisms of Immune Escape and the Tumor Microenvironment -- Drug Targets and Strategies in the Clinical Development of Immunotherapy for Head and Neck Cancer -- Immunotherapy in Locally Advanced Nasopharyngeal Carcinoma -- Immunotherapy in Recurrent and Metastatic Nasopharyngeal Carcinoma -- Beyond PD-1/PD-L1 Immune Checkpoint Inhibitors: Other Targets and Approaches for Head and Neck Cancer -- Translational and Clinical Approach to Combining Immunotherapy with Radiotherapy in the Treatment of Head and Neck Cancer -- Clinical Application of Immunotherapy in the Perioperative Management of Head and Neck Cancer -- The Role of Immune Checkpoint Inhibitors in the Treatment of Less Common Head and Neck Cancers -- Development of Predictive Biomarkers to Immunotherapy in Head and Neck Cancer. . 330 $aThis book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours has gradually brought immunotherapy into mainstream oncological practice in recent years. Besides immune-checkpoint proteins inhibitors, other forms of immunotherapy such as vaccines, EBV or HPV-targeting therapies and cellular therapies are actively being investigated in clinical trials, either alone or in combination with other conventional treatments such as radiotherapy, chemotherapy and surgery. In clinical setting, the practicing oncologist need to be familiar with some unusual patterns of immunological response such as pseudo-progression and hyper-progression in patients with head and neck cancers who are undergoing treatment with immune-checkpoint inhibitors. Furthermore, the unique side effects of immune-checkpoint inhibitors such as autoimmune toxicities need to be recognized early and treated expediently. The development of biomarkers in predicting response to immune-checkpoint inhibitors has played pivotal roles in selecting patients for immunotherapy in practice or as an enrichment strategy in clinical trials. There are now emerging data on the clinical utility of biomarkers such as PD-L1 expression (Combined Positive Score), gene signatures and tumor mutational burden. This book is an invaluable companion to all those who are involved in research and clinical management of patients with head and neck cancers from any endemic regions. . 410 0$aCancer Immunotherapy,$x2662-8392 ;$v1 606 $aImmunotherapy 606 $aOncology 606 $aMedical radiology 606 $aSurgery 606 $aOtolaryngology 606 $aHead and Neck Neoplasms$xtherapy 606 $aHead and Neck Neoplasms$xradiotherapy 606 $aImmunotherapy 606 $aImmunotherapy 606 $aOncology 606 $aRadiation Oncology 606 $aSurgery 606 $aOtorhinolaryngology 615 0$aImmunotherapy. 615 0$aOncology. 615 0$aMedical radiology. 615 0$aSurgery. 615 0$aOtolaryngology. 615 2$aHead and Neck Neoplasms$xtherapy. 615 2$aHead and Neck Neoplasms$xradiotherapy. 615 2$aImmunotherapy. 615 14$aImmunotherapy. 615 24$aOncology. 615 24$aRadiation Oncology. 615 24$aSurgery. 615 24$aOtorhinolaryngology. 676 $a615.37 676 $a571.96 700 $aChan$b Anthony T. C$01432798 701 $aMa$b Brigette B. Y$01432799 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910751389003321 996 $aImmunotherapy for Head and Neck Cancer$93577825 997 $aUNINA