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DAT$e 0102 0000017845 VPA A4(1994 40(1994), n. 13-24$fC $h19950227$i20141027$b40(1994)-41(1995). 1991-1993 in microfilm$c40(1994)-41(1995). 1991-1993 in microfilm$d 01PER. ING. DAT$e 0102 0000086825 VPA A4(1995 41(1995), n. 1-12$fC $h20110902$i20141027 977 $a 01 996 $aDatamation$9103131 997 $aUNISANNIO LEADER 04904nam 22006975 450 001 9910746999503321 005 20251008140724.0 010 $a981-19-7952-9 024 7 $a10.1007/978-981-19-7952-1 035 $a(MiAaPQ)EBC30752316 035 $a(Au-PeEL)EBL30752316 035 $a(DE-He213)978-981-19-7952-1 035 $a(PPN)27273893X 035 $a(CKB)28284160800041 035 $a(EXLCZ)9928284160800041 100 $a20230923d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDrugs and a Methodological Compendium $eFrom bench to bedside /$fedited by Vikrant Singh Rajput, Ashish Runthala 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (433 pages) 311 08$aPrint version: Rajput, Vikrant Singh Drugs and a Methodological Compendium Singapore : Springer,c2023 9789811979514 320 $aIncludes bibliographical references. 327 $aChapter 1.Computational and informatics methodologies in Drug Discovery, with focus on Natural Products -- Chapter 2.Structural biology an essential tool for Drug discovery and Development -- Chapter 3.Bioactivity guided fractionation and identification of bioactive molecules: A basic method in drug discovery -- Chapter 4.In?vitro methodologies for the safety assessment of drugs -- Chapter 5.In-vivo models for evaluation of Drug efficacy: Demand and Challenges -- Chapter 6.Preclinical In vivo Drug Development Studies: Limitations, Model Organisms and Techniques -- Chapter 7.Peptide Based Therapeutics and Drug Delivery Systems -- Chapter 8.Basics of Clinical Drug Development: Clinical Trial and Drug Development -- Chapter 9.Trailblazing contemporary frameworks for drug repurposing: A saga on drugs? expedition to disinter the veiled destiny -- Chapter 10.Small molecules as promising tool for targeted cancer therapies: an overview of 21st century -- Chapter 11.Nanoparticles for Targeted DrugDelivery Systems with Cancer Therapy in Perspective -- Chapter 12.Biomimetic approach for the controlled drug delivery through 3D bioactive scaffolds: A novel strategy for tissue engineering applications -- Chapter 13.Perspectives on anti-tuberculosis drug discovery -- Chapter 14.Cofactor-Receptor interactions based pharmacophore design for development of novel inhibitors: A case study against Tuberculosis -- Chapter 15.Insilico identification of potential antivirals against SARS-CoV2 main protease and RBD of spike protein ? A Drug Repurposing Approach -- Chapter16.Anti-malarial drug discovery and development: from bench to bedside. 330 $aThis book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines. . 606 $aBiotechnology 606 $aDrug delivery systems 606 $aBiology 606 $aPharmaceutical chemistry 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aBiotechnology 606 $aDrug Delivery 606 $aBiological Sciences 606 $aPharmaceutics 606 $aBiomedical Research 615 0$aBiotechnology. 615 0$aDrug delivery systems. 615 0$aBiology. 615 0$aPharmaceutical chemistry. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aBiotechnology. 615 24$aDrug Delivery. 615 24$aBiological Sciences. 615 24$aPharmaceutics. 615 24$aBiomedical Research. 676 $a615.1 702 $aRajput$b Vikrant Singh 702 $aRunthala$b Ashish 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910746999503321 996 $aDrugs and a Methodological Compendium$93570003 997 $aUNINA