LEADER 04019nam 22005175 450 001 9910746993803321 005 20230926132401.0 010 $a3-031-38176-9 024 7 $a10.1007/978-3-031-38176-8 035 $a(CKB)28305306900041 035 $a(MiAaPQ)EBC30755813 035 $a(Au-PeEL)EBL30755813 035 $a(DE-He213)978-3-031-38176-8 035 $a(PPN)272735116 035 $a(EXLCZ)9928305306900041 100 $a20230926d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTargeting Lysine Demethylases in Cancer and Other Human Diseases /$fedited by Qin Yan 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (187 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1433 311 $a9783031381751 327 $aChapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets. 330 $aThis book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications. The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1433 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aBiomedical Research 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aBiomedical Research. 676 $a615.35 676 $a615.35 700 $aYan$b Qin$01430240 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910746993803321 996 $aTargeting Lysine Demethylases in Cancer and Other Human Diseases$93569952 997 $aUNINA