LEADER 03561nam 22005175 450 001 9910746298603321 005 20251009082117.0 010 $a3-031-32273-8 024 7 $a10.1007/978-3-031-32273-0 035 $a(MiAaPQ)EBC30751916 035 $a(Au-PeEL)EBL30751916 035 $a(DE-He213)978-3-031-32273-0 035 $a(PPN)272739685 035 $a(CKB)28284170000041 035 $a(EXLCZ)9928284170000041 100 $a20230922d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFire and Rain $eCalifornia?s Changing Weather and Climate /$fby Stephen LaDochy, Michael Witiw 205 $a1st ed. 2023. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2023. 215 $a1 online resource (xxxiii, 249 pages) $cillustrations 311 08$aPrint version: LaDochy, Stephen Fire and Rain Cham : Springer,c2023 9783031322723 327 $aChapter 1. Introduction: The Most Climatically Diverse State in the U.S -- Chapter 2. The Physical Environment: Causes of Regional Climate Types -- Chapter 3. California Sunshine: The Most Sunshine in the U.S -- Chapter 4. Temperatures are Rising (isn?t surprising) -- Chapter 5. Fog: A Menace or Friend? -- Chapter 6. Precipitation: It Does Rain in California -- Chapter 7. Atmosphere-Ocean Interactions: Do El Niņos Predict Rainfall? -- Chapter 8. Winds: Sea Breezes and Santa Anas -- Chapter 9. Mid-latitude Cyclones: Pacific Storms Refresh the Parched Land -- Chapter 10. Thunderstorms: Lightning, Hail and Tornadoes, Oh My -- Chapter 11. Climate Change: The Future Ain?t What it Used to Be -- Chapter 12. Air Pollution: Smoggiest Place in the U.S -- Chapter 13. California Agriculture: Leading the Continent in Produce. 330 $aThis book shows how California?s weather and climate have drastically changed and what we can expect in the near future. California?s weather and climate are becoming as common a topic in the media as inflation and wars. It comes into our lives during heat waves when we require more cooling and during droughts when we are asked to limit our use of water. We may not be able to visit state and national parks when fires rage nearby. Indeed, California does have weather. LaDochy and Witiw dispel the erroneous myths about the state?s climate in a colorful, entertaining way. California does have seasons. It does rain in Southern California. It is not always sunny and mild throughout the year. And not all El Niņos bring abundant rainfall every time throughout the state. These and other myths are discussed and dismissed with the latest science and remarkable vignettes. The authors describe the diversity of the state?s physical environment, both natural and man-made and how climate change is currently altering this diverse environment. Climate change, in the past, present and future, continues to influence this most populous state. Yes, California does have weather. 606 $aClimatology 606 $aNatural disasters 606 $aClimate Sciences 606 $aNatural Hazards 615 0$aClimatology. 615 0$aNatural disasters. 615 14$aClimate Sciences. 615 24$aNatural Hazards. 676 $a551.69794 700 $aLaDochy$b Stephen$01429557 701 $aWitiw$b Michael$01429558 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910746298603321 996 $aFire and Rain$93568556 997 $aUNINA LEADER 04651nam 22006015 450 001 9910300187903321 005 20200703025156.0 010 $a3-319-09915-9 024 7 $a10.1007/978-3-319-09915-6 035 $a(CKB)3710000000291462 035 $a(EBL)1965246 035 $a(OCoLC)908083223 035 $a(SSID)ssj0001386583 035 $a(PQKBManifestationID)11799006 035 $a(PQKBTitleCode)TC0001386583 035 $a(PQKBWorkID)11374164 035 $a(PQKB)11363818 035 $a(DE-He213)978-3-319-09915-6 035 $a(MiAaPQ)EBC1965246 035 $a(PPN)183088379 035 $a(EXLCZ)993710000000291462 100 $a20141118d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLeptin $eRegulation and Clinical Applications /$fedited by Sam Dagogo-Jack, MD 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (299 p.) 300 $aDescription based upon print version of record. 311 $a3-319-09914-0 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aDiscovery of leptin and elucidation of leptin gene expression -- Leptin receptors and mechanism of action -- Leptin interaction with brain orexigenic and anorexigenic pathways -- Measurement of circulating leptin and soluble leptin receptors -- Physiological and hormonal factors that influence leptin production -- Leptin, obesity and leptin resistance -- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism -- Leptin in acute stress -- Leptin and the kidney -- Leptin, immune function, and inflammation -- Leptin and bone -- Leptin, cell cycle, and cancer -- Leptin, the autonomic nervous system, and hypertension -- Dynamic leptin secretion in obesity and diabetes -- Leptin therapy of congenital leptin deficiency -- Leptin therapy in people with normal leptin gene -- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance -- Leptin therapy in women with hypothalamic amenorrhea -- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans -- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases. 330 $aTwenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders. 606 $aEndocrinology 606 $aMetabolism$xDisorders 606 $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053 606 $aMetabolic Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33118 615 0$aEndocrinology. 615 0$aMetabolism$xDisorders. 615 14$aEndocrinology. 615 24$aMetabolic Diseases. 676 $a610 676 $a612.6 676 $a616.39 676 $a616.4 702 $aDagogo-Jack$b MD, Sam$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300187903321 996 $aLeptin$92522510 997 $aUNINA