LEADER 04593nam 22007335 450 001 9910746098203321 005 20251128155604.0 010 $a3-031-26098-8 024 7 $a10.1007/978-3-031-26098-8 035 $a(MiAaPQ)EBC30739079 035 $a(Au-PeEL)EBL30739079 035 $a(DE-He213)978-3-031-26098-8 035 $a(OCoLC) 1397569558 035 $a(PPN)27273909X 035 $a(CKB)28204510400041 035 $a(EXLCZ)9928204510400041 100 $a20230911d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClinical Neuroembryology $eDevelopment and Developmental Disorders of the Human Central Nervous System /$fby Hans J. ten Donkelaar, Martin Lammens, Akira Hori 205 $a3rd ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (926 pages) 311 08$aPrint version: ten Donkelaar, Hans J. Clinical Neuroembryology Cham : Springer International Publishing AG,c2023 9783031260971 320 $aIncludes bibliographical references and index. 327 $aOverview of the Development of the Human Brain and Spinal Cord -- Mechanisms of Development -- Causes of Congenital Malformations -- Neurulation and Neurulation Defects -- The Neural Crest and Craniofacial Malformations -- Development and Developmental Disorders of the Spinal Cord -- Development and Developmental Disorders of the Brain Stem -- Development and Developmental Disorders of the Human Cerebellum -- Development and Developmental Disorders of the Forebrain -- Development and Developmental Disorders of the Cerebral Cortex. 330 $aThis book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved. In the third edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology. 606 $aDevelopmental neurobiology 606 $aNeuroanatomy 606 $aNervous system$xDiseases 606 $aNeurosciences 606 $aNeurology 606 $aDevelopment of the Nervous System 606 $aNeuroanatomy 606 $aNeurological Disorders 606 $aNeuroscience 606 $aNeurology 606 $aNeurobiologia del desenvolupament$2thub 606 $aMalalties del sistema nerviós central$2thub 608 $aLlibres electrònics$2thub 615 0$aDevelopmental neurobiology. 615 0$aNeuroanatomy. 615 0$aNervous system$xDiseases. 615 0$aNeurosciences. 615 0$aNeurology. 615 14$aDevelopment of the Nervous System. 615 24$aNeuroanatomy. 615 24$aNeurological Disorders. 615 24$aNeuroscience. 615 24$aNeurology. 615 7$aNeurobiologia del desenvolupament 615 7$aMalalties del sistema nerviós central 676 $a612.8 700 $aten Donkelaar$b Hans J.$0897748 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910746098203321 996 $aClinical Neuroembryology$92519595 997 $aUNINA