LEADER 00961nlm 2200289 a 450 001 996599071603316 005 20240606103927.0 100 $a19800605d1932---- uy 0 101 0 $aeng 135 $adrcnu 200 1 $aIntroduction to the study of history$fby Ch. V. Langlois & Ch. Seignobos$gtranslated by G.G. Berry$gwith a preface by F. York Powell 210 1 $aNew York$cH. 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Building a model is usually a relatively easy task, but making it an accurate representation of the phenomenon to be reproduced is a completely different matter. It is well-known that to increase the ability to build reliable models it is necessary to accumulate experience. The book addresses this need by presenting a collection of case studies of increasing complexity. Readers are introduced to the modeling process gradually, learning the basic concepts step-by-step as they go through the case studies. Queueing Networks are used to design the models solved with simulation and analytical techniques from the open source Java Modelling Tools (JMT). Among the models analyzed there are systems for optimizing performance, identifying bottlenecks, evaluating the impact of the variability of traffic and service demands, analyzing the effects of synchronization policies in parallel computing. Four case studies derived from real-life scenarios are also presented: a surveillance system, autoscaling load fluctuations, web app workflow simulation, and crowd computing platform. This book serves as a reference tool for graduate and senior-level computer science students in courses of performance evaluation and modeling, as well as for researchers and practitioners. . 606 $aElectronic digital computers$xEvaluation 606 $aElectronic circuits 606 $aComputer networks 606 $aSoftware engineering 606 $aSystem Performance and Evaluation 606 $aElectronic Circuits and Systems 606 $aComputer Networks 606 $aSoftware Engineering 615 0$aElectronic digital computers$xEvaluation. 615 0$aElectronic circuits. 615 0$aComputer networks. 615 0$aSoftware engineering. 615 14$aSystem Performance and Evaluation. 615 24$aElectronic Circuits and Systems. 615 24$aComputer Networks. 615 24$aSoftware Engineering. 676 $a004.24 686 $aCOM051230$aCOM074000$aTEC008010$aTEC041000$2bisacsh 700 $aSerazzi$b Giuseppe$4aut$4http://id.loc.gov/vocabulary/relators/aut$0751 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910745585003321 996 $aPerformance Engineering$93573114 997 $aUNINA LEADER 02868nam 2200457z- 450 001 9910136803103321 005 20210212 035 $a(CKB)3710000000631102 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58581 035 $a(oapen)doab58581 035 $a(EXLCZ)993710000000631102 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Role of Glia in Plasticity and Behavior 210 $cFrontiers Media SA$d2015 215 $a1 online resource (104 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-690-9 330 $aGlial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function. 606 $aNeurosciences$2bicssc 610 $aAstrocytes 610 $aBehavior 610 $aC. elegans 610 $aCerebellum 610 $aCortex 610 $aDREADD 610 $aglia 610 $aGq 610 $aHippocampus 610 $aplasticity 615 7$aNeurosciences 700 $aTycho Hoogland$4auth$01332333 702 $aParpura$b Vladimir$f1964-$4auth 906 $aBOOK 912 $a9910136803103321 996 $aThe Role of Glia in Plasticity and Behavior$93040850 997 $aUNINA