LEADER 04668nam 22007095 450 001 9910743697703321 005 20250703211359.0 010 $a981-9926-57-2 024 7 $a10.1007/978-981-99-2657-2 035 $a(MiAaPQ)EBC30726122 035 $a(CKB)28131537000041 035 $a(Au-PeEL)EBL30726122 035 $a(DE-He213)978-981-99-2657-2 035 $a(PPN)272273120 035 $a(EXLCZ)9928131537000041 100 $a20230831d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDeciphering Drug Targets for Alzheimer?s Disease /$fedited by Dileep Kumar, Vaishali M. Patil, Dee Wu, Nanasaheb Thorat 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (388 pages) 311 08$a9789819926565 327 $aChapter 1.Deciphering New Drug Targets in Alzheimer?s Disease -- Chapter 2. Novel Therapeutic Targets for Treating Alzheimer?s Disease -- Chapter 3. Modified Investigation Tools and Techniques Useful in Alzheimer?s Disease Research -- Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer?s Disease -- Chapter 5. ?-secretase as a primary drug target of Alzheimer disease: Function, Structure, and Inhibition -- Chapter 6. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer?s -- Chapter 7. Calcium Channels as a Potential Therapeutic Target for Alzheimer?s Disease -- Chapter 8. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimer?s Disease -- Chapter 9. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer?s Disease -- Chapter 10. Epigenetic Therapy for Alzheimer?s Disease -- Chapter 11. Exploring the Diverse Roles of GSK-3ß Kinase in Alzheimer?s Disease -- Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimer?s Agents: In Silico Applications -- Chapter 13. Multi-Target Directed Ligand Approach in Anti-Alzheimer?s Drug Discovery -- Chapter 14. Investigating the Role of Tau Proteins in Alzheimer?s Disease-From Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain -- Chapter 15. The Overview of Drugs Used in Alzheimer?s Disease and Their Molecular Targets. 330 $aThis book explains the fundamental characteristics and biofunctionality of Alzheimer?s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer?s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer?s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer?s disease treatment. 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aBiology 606 $aNeurosciences 606 $aBiotechnology 606 $aDrug delivery systems 606 $aBiomedical Research 606 $aBiological Sciences 606 $aNeuroscience 606 $aBiotechnology 606 $aDrug Delivery 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aBiology. 615 0$aNeurosciences. 615 0$aBiotechnology. 615 0$aDrug delivery systems. 615 14$aBiomedical Research. 615 24$aBiological Sciences. 615 24$aNeuroscience. 615 24$aBiotechnology. 615 24$aDrug Delivery. 676 $a616.8311061 700 $aKumar$b Dileep$01426826 701 $aPatil$b Vaishali Manikrao$01828543 701 $aWu$b Dee$c(Professor at University of Oklahoma Health Sciences Center)$01831376 701 $aThorat$b Nanasaheb D$01831377 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910743697703321 996 $aDeciphering Drug Targets for Alzheimer?s Disease$94403617 997 $aUNINA