LEADER 05511nam 22007455 450 001 9910743362403321 005 20251113210501.0 010 $a981-16-9080-4 010 $a981-16-9081-2 010 $a981-16-9081-2 024 7 $a10.1007/978-981-16-9081-5 035 $a(MiAaPQ)EBC6944407 035 $a(Au-PeEL)EBL6944407 035 $a(CKB)21459773900041 035 $a(PPN)261524895 035 $a(OCoLC)1311273394 035 $a(DE-He213)978-981-16-9081-5 035 $a(EXLCZ)9921459773900041 100 $a20220331d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGlycobiology of Innate Immunology /$fby Cheorl-Ho Kim 205 $a1st ed. 2022. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022. 215 $a1 online resource (673 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$aPrint version: Kim, Cheorl-Ho Glycobiology of Innate Immunology Singapore : Springer Singapore Pte. Limited,c2022 9789811690808 320 $aIncludes bibliographical references. 327 $aPart 1. Glycans in innate immunity of dendritic cells -- Chapter 1) Historical expansion of defense system -- Chapter 2) Columbus era to modern revolution in immunological defense system -- Chapter 3) Historical profile of defense constituents and progress in innte immune repertoire -- Chapter 4) The outline of innate immunity -- Chapter 5) Autophagy from microbial invaders and self-associated molecular patterns (SAMPs) of innate immune cells -- Part 2. Dendritic cells (DCs) -- Chapter 6) General biology of DCs -- Chapter 7) Classification and different function of DCs -- Chapter 8) Glycan biosynthesis in eukaryotes -- Chapter 9) Glycans in cell recognition and evolutionary adaptation in organisms -- Chapter 10) Changes in glycan structure involve in co-regulated expression of glycan-binding lectin counterparts -- Chapter 11) Evolution of lectin: alternative splicing contributes to variation for glycan binding receptors -- Chapter 12) Glycan regulation of NK cell receptors -- Chapter 13) Carbohydrate recognition of target antigens by DCs during infection and inflammation -- Chapter 14) Glycan-specific trafficking receptors in DCs maturation -- Chapter 15) Glycan ligands in trafficking of DC migration -- Chapter 16) Chemokine receptors in DCs trafficking -- Chapter 17) Glycan structure-recognizing selectins in DC-endothelium interaction during infection and inflammation -- Chapter 18) Glycans activate the innate immune system -- Chapter 19) Innate immune lectin receptors of Siglec, DC-SIGN, Galectin and TLR in DCs -- Chapter 20) Galectins -- Chapter 21) DC-specific ICAM-3-grabbing non-integrin, DC-SIGNB (CD209) -- Chapter 22) Other DCs-derivd receptors -- Chapter 23) Toll-like receptors (TLRs) -- Chapter 24) CD33 and CD33-related Siglecs in pathogen recognition and endocytosis of DC in the innate immune system -- Chapter 25) Pathogenic suppression of the pathogen-specific host immune response -- Chapter 26) DCs tumor immunotherapy through sialyl binding of DCs to T cells. 330 $aThis book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell?cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein?carbohydrate or carbohydrate?carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases. 410 0$aBiomedical and Life Sciences Series 606 $aGenetics 606 $aMedical genetics 606 $aBiology 606 $aMembranes (Biology) 606 $aBiological transport 606 $aCell membranes 606 $aGenetics and Genomics 606 $aMedical Genetics 606 $aBiological Sciences 606 $aBiological Membranes 606 $aMembrane Trafficking 615 0$aGenetics. 615 0$aMedical genetics. 615 0$aBiology. 615 0$aMembranes (Biology) 615 0$aBiological transport. 615 0$aCell membranes. 615 14$aGenetics and Genomics. 615 24$aMedical Genetics. 615 24$aBiological Sciences. 615 24$aBiological Membranes. 615 24$aMembrane Trafficking. 676 $a301 700 $aKim$b Cheorl-Ho$01062709 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910743362403321 996 $aGlycobiology of innate immunology$93560461 997 $aUNINA