LEADER 04131nam 2200961z- 450 001 9910743269903321 005 20230911 035 $a(CKB)5690000000228609 035 $a(oapen)doab113979 035 $a(EXLCZ)995690000000228609 100 $a20230920c2023uuuu -u- - 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGlutathione: Chemistry and Biochemistry 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2023 215 $a1 online resource (212 p.) 311 08$a3-0365-8666-0 330 $aIt has been known that cellular glutathione content and its speciation play a role, among others, in redox homeostasis, cell cycle control, immunological defense, and pathological abnormalities. Furthermore, it plays a significant role in the biotransformation of drugs and other endogenous or exogenous electrophilic species. Most of these cellular functions are related to the thiol function of the cysteine moiety.This reprint presents the publications that appeared in the Special Issue of Molecules, "Glutathione: Chemistry and Biochemistry." The first three contributions review the present-day knowledge of the GSH/GSSG system and the most important GSH-related proteins involved in regulating various cellular events. The subsequent four contributions present selected interventions that modulate the GSSG/2GSH system. One of the contributions to this session describes a new HPLC method to quantify the reduced and oxidized glutathione levels. The third session involves three contributions demonstrating the role of GSH in the metabolism of different candidate and clinically used anticancer drugs. One of the contributions, a theoretical work, provides helpful information for developing GSH analogs with high ACE inhibitor activity.By purpose and content, this Special Issue is addressed to the vast number of life science researchers (academic and industrial) and medical professionals who are interested in or already engaged in research that involves glutathione. 517 $aGlutathione 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $aangiotensin-converting enzyme 610 $aanticancer drugs 610 $aapoptosis 610 $aautoimmune diseases 610 $abioactivation 610 $abrain 610 $acell 610 $acell injury 610 $achalcone 610 $acyclophosphamide 610 $acysteine 610 $adetoxification 610 $aDFT 610 $adiastereoselective addition 610 $adiode array detector 610 $aendothelial cells 610 $afluorescence probes 610 $aGCLc 610 $aglutaredoxin 610 $aglutathione 610 $aglutathione enzyme 610 $aglutathione system 610 $aglutathione-S-transferase 610 $aglutathionylation 610 $aGSH 610 $aGSS 610 $aGSSG 610 $airon 610 $airon-sulfur cluster 610 $aischemia 610 $aliquid chromatography 610 $aM06-2X/6-311++G(d,p) 610 $amechanisms of glutathione conjugation reaction 610 $aMichael addition 610 $amolecular docking 610 $an/a 610 $ananotoxicity 610 $anitrosoglutathione 610 $aoxidative stress 610 $apharmacokinetics 610 $aphysicochemical properties 610 $apolymerized whey protein 610 $apolymorphism 610 $areactive oxygen species 610 $aredox homeostasis 610 $aredox potential 610 $aredox-regulation 610 $aS-glutathionylation 610 $aS-nitrosylation 610 $asulodexide 610 $asupramolecular arrangement 610 $athiols 610 $atoxicity 615 7$aBiology, life sciences 615 7$aResearch and information: general 906 $aBOOK 912 $a9910743269903321 996 $aGlutathione: Chemistry and Biochemistry$93560498 997 $aUNINA