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010   $a1-299-40807-9
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024 7 $a10.1007/978-94-007-6028-8
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035   $a(EBL)1083708
035   $a(OCoLC)828794536
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035   $a(PQKBTitleCode)TC0000879844
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035   $a(DE-He213)978-94-007-6028-8
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035   $a(PPN)168342197
035   $a(EXLCZ)992670000000338269
100   $a20130228d2013      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aTight Junctions in Cancer Metastasis$b[electronic resource] /$fedited by Tracey A. Martin, Wen G. Jiang
205   $a1st ed. 2013.
210  1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013.
215   $a1 online resource (315 p.)
225 1 $aCancer Metastasis - Biology and Treatment,$x1568-2102
300   $aDescription based upon print version of record.
311   $a94-007-9806-7 
311   $a94-007-6027-2 
320   $aIncludes bibliographical references and index.
327   $aPreface -- The molecular aspects of Tight junctions -- The distribution of tight junctions and junctional proteins in the body -- Methodologies in investigation tight junctions -- Vascular permeability and drug delivery -- Tight junctions, BBB and brain metastasis -- Tight junctions and bladder cancer metastasis -- Tight Junctions and colorectal cancer therapies -- Tight junctions in breast cancer -- Regulation of tight junctions for therapeutic advantages -- Overcoming tight junctional permeability in cerebral metastasis -- CL-5 and cancer metastasis -- Intracellular signalling in TJ and AJ -- ROCK and TJ -- Index.
330   $aThere has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
410  0$aCancer Metastasis - Biology and Treatment,$x1568-2102
606   $aMedicine
606   $aCancer research
606   $aOncology  
606   $aCell biology
606   $aCell membranes 
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050
615  0$aMedicine.
615  0$aCancer research.
615  0$aOncology  .
615  0$aCell biology.
615  0$aCell membranes .
615 14$aBiomedicine, general.
615 24$aCancer Research.
615 24$aOncology.
615 24$aCell Biology.
615 24$aMembrane Biology.
676   $a616.99
676   $a616.99/4
702   $aMartin$b Tracey A$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aJiang$b Wen G$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910741198803321
996   $aTight Junctions in Cancer Metastasis$93554236
997   $aUNINA