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024 7 $a10.1007/978-94-007-5943-5
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035   $a(EBL)1083688
035   $a(OCoLC)824118112
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035   $a(DE-He213)978-94-007-5943-5
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100   $a20130204d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aImmunity, tumors and aging $ethe role of HSP70 /$fIgor Malyshev
205   $a1st ed. 2013.
210   $aDordrecht ;$aNew York $cSpringer$d2013
215   $a1 online resource (144 p.)
225 0 $aSpringerbriefs in biochemistry and molecular biology
300   $aDescription based upon print version of record.
311   $a94-007-5942-8 
320   $aIncludes bibliographical references and index.
327   $aForward -- Introduction -- 1 A General Description of HSPs, The Molecular Structure of HSP70, The HSP70 Cycle -- 2 HSP70 Functions In Normal Cells -- 3 HSP70 IN A Damaged Cells -- 4 Mechanisms Of Activation And Inactivation Of HSP70 Synthesis -- 5 HSP70 In The Immune Responses -- 6 HSP70 in Carcinogenesis -- 7 HSP70 In Aging -- 8 The Role Of HSP70 in Protection of (a) The Brain In Alzheimer?s Disease, and (b) The Heart -- Index.
330   $aThe book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiosurgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.
410  0$aSpringerBriefs in Biochemistry and Molecular Biology,$x2211-9353
606   $aCancer$xAge factors
606   $aCancer$xImmunological aspects
606   $aHeat shock proteins
615  0$aCancer$xAge factors.
615  0$aCancer$xImmunological aspects.
615  0$aHeat shock proteins.
676   $a572.6
700   $aMalyshev$b Igor$01424076
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910741189503321
996   $aImmunity, tumors and aging$94187034
997   $aUNINA