LEADER 02664nam 2200565 a 450 001 9910741183103321 005 20200520144314.0 010 $a3-319-00303-8 024 7 $a10.1007/978-3-319-00303-0 035 $a(CKB)2670000000371233 035 $a(EBL)1317006 035 $a(SSID)ssj0000894401 035 $a(PQKBManifestationID)11436495 035 $a(PQKBTitleCode)TC0000894401 035 $a(PQKBWorkID)10835244 035 $a(PQKB)10385878 035 $a(DE-He213)978-3-319-00303-0 035 $a(MiAaPQ)EBC1317006 035 $a(PPN)170489531 035 $a(EXLCZ)992670000000371233 100 $a20130424d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIron acquisition by the genus Mycobacterium $ehistory, mechanisms, role of siderocalin, anti-tuberculosis drug development /$fB. Rowe Byers, editor 205 $a1st ed. 2013. 210 $aCham [Germany] $cNew York $cSpringer$d2013 215 $a1 online resource (96 p.) 225 1 $aSpringerBriefs in molecular science. Biometals,$x2212-9901 300 $aDescription based upon print version of record. 311 $a3-319-00302-X 320 $aIncludes bibliographical references and index. 327 $aA History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform. 330 $aIron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates. 410 0$aSpringerBriefs in molecular science.$pBiometals. 606 $aIron proteins 606 $aMycobacteria 615 0$aIron proteins. 615 0$aMycobacteria. 676 $a572.517 701 $aByers$b B. Rowe$01762196 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910741183103321 996 $aIron acquisition by the genus Mycobacterium$94201977 997 $aUNINA