LEADER 03351nam 2200601 a 450 001 9910739442903321 005 20200520144314.0 010 $a1-4614-7855-3 024 7 $a10.1007/978-1-4614-7855-3 035 $a(CKB)2670000000530509 035 $a(EBL)1398484 035 $a(OCoLC)858763715 035 $a(SSID)ssj0000986618 035 $a(PQKBManifestationID)11586560 035 $a(PQKBTitleCode)TC0000986618 035 $a(PQKBWorkID)10942163 035 $a(PQKB)11554079 035 $a(DE-He213)978-1-4614-7855-3 035 $a(MiAaPQ)EBC1398484 035 $a(PPN)172420083 035 $a(EXLCZ)992670000000530509 100 $a20130717d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProtein tyrosine phosphatase control of metabolism /$fKendra K. Bence, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (279 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-7854-5 311 $a1-4899-9798-9 320 $aIncludes bibliographical references and index. 327 $aRedox Regulation of PTPs in Metabolism: Focus on Assays -- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling -- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism -- PTP1B and TCPTP in CNS Signaling and Energy Balance -- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress -- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling -- PTP1B in Obesity-Related Cardiovascular Runction -- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism -- Metabolic Effects of Neural and Pancreatic SHP2 -- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism -- The Role of LMPTP in the Metabolic Syndrome -- Mitogen-Activated Protein Kinase Phosphatases in Metabolism -- Glycogen Metabolism and Lafora Disease -- Index. 330 $aTyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs).  A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes.  Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions.  This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. 606 $aProtein-tyrosine phosphatase$xPhysiological effect 606 $aMetabolism$xRegulation 615 0$aProtein-tyrosine phosphatase$xPhysiological effect. 615 0$aMetabolism$xRegulation. 676 $a570 676 $a572 676 $a572.6 676 $a610 701 $aBence$b Kendra K$01754804 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739442903321 996 $aProtein tyrosine phosphatase control of metabolism$94191299 997 $aUNINA