LEADER 03859nam 2200613Ia 450 001 9910739442603321 005 20200520144314.0 010 $a1-4614-7678-X 024 7 $a10.1007/978-1-4614-7678-8 035 $a(CKB)2670000000530496 035 $a(EBL)1398462 035 $a(OCoLC)858763537 035 $a(SSID)ssj0000988060 035 $a(PQKBManifestationID)11534662 035 $a(PQKBTitleCode)TC0000988060 035 $a(PQKBWorkID)10950642 035 $a(PQKB)11478430 035 $a(DE-He213)978-1-4614-7678-8 035 $a(MiAaPQ)EBC1398462 035 $a(PPN)172419700 035 $a(EXLCZ)992670000000530496 100 $a20111102d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiophysics of the failing heart $ephysics and biology of heart muscle /$fR. John Solaro, Jil C. Tardiff, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer Science$d2013 215 $a1 online resource (254 p.) 225 0 $aBiological and medical physics, biomedical engineering 300 $aDescription based upon print version of record. 311 $a1-4614-7677-1 311 $a1-4939-0185-0 320 $aIncludes bibliographical references and index. 327 $aChapter 1 Introduction to the Biophysics of the Failing Heart -- Chapter 2 Sarcoplasmic reticulum Ca homeostasis and Heart Failure -- Chapter 3 Ca-homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes -- Chapter 4 Biophysics of Membrane Currents in Heart Failure -- Chapter 5 Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function -- Chapter 6 Cytoskeletal Nuclear Links in the Cardiomyocyte -- Chapter 7 Biophysical Forces Modulate the Costamere and Z-Disc -- Chapter 8 Heart failure- the final frontier for biophysics in cardiovascular medicine? -- Chapter 9 Arrhythmogenesis, Heart Failure, and the Biophysics of Z-band Protein Networks -- Chapter 10 Biophysics of Titin in Cardiac Health and Disease -- Chapter 11 Sarcomeres and the Biophysics of Heart Failure -- Index. 330 $aBiophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels. 410 0$aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 606 $aHeart failure$xPathophysiology 606 $aHeart$xPhysiology 615 0$aHeart failure$xPathophysiology. 615 0$aHeart$xPhysiology. 676 $a616.12 676 $a616/.014 701 $aSolaro$b R. John$01755093 701 $aTardiff$b Jill C$01755094 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739442603321 996 $aBiophysics of the failing heart$94191721 997 $aUNINA